This trial is active, not recruiting.

Conditions ds stage i plasma cell myeloma, ds stage ii plasma cell myeloma, ds stage iii plasma cell myeloma, refractory plasma cell myeloma
Treatments busulfan, melphalan, bortezomib, autologous hematopoietic stem cell transplantation, peripheral blood stem cell transplantation, laboratory biomarker analysis, pharmacological study
Phase phase 2
Target proteasome
Sponsor Albert Einstein College of Medicine of Yeshiva University
Collaborator National Cancer Institute (NCI)
Start date February 2012
End date January 2017
Trial size 42 participants
Trial identifier NCT01605032, 11-102, 11-12-434, NCI-2013-01207, P30CA013330


This phase II trial studies how well busulfan, melphalan, and bortezomib before first-line stem cell transplant works in treating patients with multiple myeloma. Giving chemotherapy before a peripheral blood stem cell transplant may stop the growth of cancer cells by stopping them from dividing or killing them. After treatment, stem cells are collected from the patient's blood and stored. The stem cells are then returned to the patient to replace the blood-forming cells that were destroyed by the chemotherapy.

United States No locations recruiting
Other countries No locations recruiting

Study Design

Endpoint classification efficacy study
Intervention model single group assignment
Masking open label
Primary purpose treatment
CONDITIONING: Patients receive busulfan IV over 3 hours on days -6 to -3, melphalan IV over 20 minutes on day -2, and bortezomib IV over 3-5 seconds on days -6, -3, 1, and 4. TRANSPLANT: Patients undergo autologous PBSCT on day 0.
Given IV
melphalan Alkeran
Given IV
Given IV
autologous hematopoietic stem cell transplantation Autologous Stem Cell Transplantation
Undergo autologous PBSCT
peripheral blood stem cell transplantation PBPC transplantation
Undergo autologous PBSCT
laboratory biomarker analysis
Correlative studies
pharmacological study pharmacological studies
Correlative studies

Primary Outcomes

Rate of complete response as determined by the IMWG criteria
time frame: Day 100

Secondary Outcomes

Overall response rate, defined as the percentage of participants that achieve either stringent complete response, CR, very good partial response plus partial response)
time frame: Up to day 360
Incidence of toxicity assessed using National Cancer Institute Common Terminology Criteria for Adverse Events version 4.0
time frame: Up to 5 years
time frame: Up to day 360
time frame: From start of treatment to disease progression with deaths, up to 5 years
Progression-free survival
time frame: From transplant (day 0) to time of progression, assessed up to 5 years
Event-free survival
time frame: From stem cell transplant until an event (disease progression or death from any cause) has occurred, assessed up to 5 years
Overall survival
time frame: From transplant until death of any cause, assessed up to 5 years
Pharmacokinetic parameters of busulfan
time frame: Day -6: end of infusion (EOI), EOI + 15 minutes (+/- 2 minutes), EOI + 30 minutes (+/- 2 minutes), and 240, 300 and 360 minutes (+/- 10 minutes) after the start of the infusion
Methylation expression profile
time frame: Baseline
Gene expression profile
time frame: Baseline

Eligibility Criteria

Male or female participants from 18 years up to 72 years old.

Inclusion Criteria: - Patients must have histologically or cytologically confirmed multiple myeloma - Measurable disease must be present as defined by protein criteria (quantifiable M-component in serum, urine or serum free light chains) in order to evaluate response as per IMWG; non-secretory patients are eligible provided the patient has > 20% plasmacytosis OR multiple (> 3) focal plasmacytomas or focal lesions on magnetic resonance imaging (MRI) - Patients must have received induction chemotherapy for myeloma, but not more than 12 months of prior chemotherapy for this disease, and must be eligible for the first planned autologous transplant - A minimum stem cell dose of 2.0 x 10^6 cluster of differentiation 34-positive (CD34+) cells/kg has been collected - Life expectancy of greater than 12 months - Eastern Cooperative Oncology Group (ECOG) performance status =< 2 (Karnofsky >= 60%) - Leukocytes >= 3,000/mcL (unless myeloma related) - Absolute neutrophil count >= 1,500/mcL (unless myeloma related) - Platelets >= 50,000/mcL (unless myeloma related) - Total bilirubin =< 2 x institutional upper limit of normal unless 2nd to Gilbert's disease - Aspartate aminotransferase (AST) (serum glutamic oxaloacetic transaminase [SGOT])/alanine aminotransferase (ALT) (serum glutamate pyruvate transaminase [SGPT]) =< 3 x institutional upper limit of normal - Creatinine =< 1.5 x institutional upper limit of normal OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal - Ejection fraction by echocardiogram (ECHO) or multi gated acquisition scan (MUGA) >= 40% performed within 60 days prior to registration - Patients must have adequate pulmonary function studies: > 50% of predicted on mechanical aspects (forced expiratory volume in one second [FEV1], forced vital capacity [FVC]) and diffusion capacity (diffusing capacity of the lung for carbon monoxide [DLCO]) > 50% of predicted, within 60 days of registration; if the patients is unable to complete pulmonary function tests due to multiple myeloma (MM) related pain or condition, exception may be granted if the principal investigator (PI) documents that the patient is a candidate for high dose therapy - Women of child-bearing potential and men must agree to use adequate contraception (hormonal or barrier method of birth control; abstinence) prior to study entry and for at least six months following the stem cell transplantation; should a woman become pregnant or suspect she is pregnant while participating in this study, she should inform her treating physician immediately - Ability to understand and the willingness to sign a written informed consent document Exclusion Criteria: - Patients who have had chemotherapy or radiotherapy within 4 weeks prior to entering the study or those who have not recovered from adverse events due to agents administered more than 4 weeks earlier - Prior treatment history of autologous hematopoietic stem cell transplant (HSCT) or high-dose chemotherapy with stem cell rescue for any medical reason, not limited to myeloma treatment - Patients may not be receiving any other investigational agents - Patients with known brain metastases should be excluded from this clinical trial - History of allergic reactions attributed to compounds of similar chemical or biologic composition to or other agents used in the study, such as busulfan, melphalan, bortezomib, boron, or mannitol - Grade 2 or greater peripheral neuropathy within 14 days prior to enrollment - Unresolved grade >= 3 non-hematologic toxicity from previous therapy; patients with grade 2 toxicity will be eligible at the discretion of the PI - Prior malignancies except resected basal cell carcinoma or treated cervical carcinoma in situ; cancer treated with curative intent < 5 years will not be allowed unless approved by the PI; cancer treated with curative intent > 5 years will be allowed - Patients must not have significant co-morbid medical condition - Uncontrolled intercurrent illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements; patients must not have suffered recent (< 6 months) myocardial infarction, unstable angina, difficult to control congestive heart failure, uncontrolled hypertension, or difficult to control cardiac arrhythmias - Pregnant women are excluded from this study; breastfeeding should be discontinued if the mother is treated with busulfan - Human immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligible - Patients found to have an active hepatitis B infection (hepatitis B surface antigen +) are not eligible unless they meet ONE of the following criteria: - Patient is able to start dual anti-hepatitis (Hep) B therapy prior to enrollment with adefovir and telbivudine - Patient is already on dual anti-hepatitis B therapy - Consultation and co-management with a hepatitis expert regarding hepatitis B treatment is strongly encouraged before and during the trial - Patients, who are positive for hepatitis B core antibody, but negative for the hepatitis B surface antigen, should be started on lamivudine 100 mg daily until at least 3 months post stem cell transplant

Additional Information

Official title Phase II Study Assessing the Efficacy and Toxicity of PK--directed Intravenous Busulfan in Combination With High--Dose Melphalan and Bortezomib as Conditioning Regimen for First--Line Autologous Hematopoietic Stem Cell Transplantation in Patients With Multiple Myeloma
Principal investigator Ira Braunschweig
Description PRIMARY OBJECTIVES: I. To determine the complete response rate as defined by the International Myeloma Working Group (IMWG) criteria for patients with multiple myeloma treated with high dose chemotherapy with pharmacokinetic (PK) directed intravenous (IV) busulfan, bortezomib and melphalan (Bu/BTZ/Mel140) followed by autologous hematopoietic stem cell transplantation (ASCT) as first line therapy. SECONDARY OBJECTIVES: I. To determine the overall response rate of the regimen Bu/BTZ/Mel140. II. To determine the treatment related toxicity and mortality of the regimen, including 100-day mortality rates. III. To determine the duration of response, time to progression, progression-free survival, event-free survival and overall survival for this conditioning regimen. IV. To determine whether there is a gender or race difference in the pharmacokinetic profile of IV busulfan. V. To determine methylation and gene expression signatures of pre-treatment bone marrow plasma cells and explore associations of these signatures with outcome. OUTLINE: CONDITIONING: Patients receive busulfan IV over 3 hours on days -6 to -3, melphalan IV over 20 minutes on day -2, and bortezomib IV over 3-5 seconds on days -6, -3, 1, and 4. TRANSPLANT: Patients undergo autologous peripheral blood stem cell transplant (PBSCT) on day 0. After completion of study treatment, patients are followed up for up to 5 years.
Trial information was received from ClinicalTrials.gov and was last updated in January 2016.
Information provided to ClinicalTrials.gov by Albert Einstein College of Medicine of Yeshiva University.