Anodal and Cathodal Transcranial Direct Current Stimulation in Stroke Recovery
This trial is active, not recruiting.
|Treatments||transcranial direct current stimulation (anodal), transcranial direct current stimulation (cathodal), transcranial direct current stimulation (sham)|
|Sponsor||Dina Hatem Elhammady|
|Start date||January 2011|
|End date||May 2012|
|Trial size||40 participants|
|Trial identifier||NCT01601392, tDCS in stroke recovery|
The purpose of this study will to compare the long-term effect of anodal versus cathodal transcranial direct current stimulation (tDCS) on motor recovery in subacute stroke patients. Forty patients with subacute ischemic stroke will randomly assigned to one of three groups: Anodal, Cathodal and Sham. Each group will receive tDCS at an intensity of 2mA for 25 minutes daily for 6 consecutive days over the affected (Anodal, Sham) or unaffected (Cathodal) motor cortex. Patients will be assessed with National Institutes of Health Stroke Scale (NIHSS), the Barthel index (BI) and the Medical Research Council (MRC) muscle strength scale at baseline, after end of the 6th tDCS session, and then 1, 2 and 3 months later. Motor cortical excitability will be measured at baseline and after the 6th session in both hemispheres.
|Endpoint classification||efficacy study|
|Intervention model||parallel assignment|
Motor power improvement
time frame: 3 Months
Motor cortical excitability
time frame: 1 Month
Male or female participants from 40 years up to 70 years old.
- acute hemiparesis with single thromboembolic non-hemorrhagic infarction documented by magnetic resonance imaging (MRI)
- Accept to participate in the study
- extensive infarction (taking all territories of middle cerebral artery)
- severe flaccid hemiplegia
- head injury
- Any other neurological disease other than stroke
- previous administration of tranquilizer
- patients who are unable to give informed consent because of severe aphasia, or cognitive deficit.
- Patients with no motor evoked response recorded from First Dorsal Interosseus (FDI) muscle of the affected hand
|Official title||Effect of Anodal Versus Cathodal Transcranial Direct Current Stimulation on Stroke Recovery: a Pilot Randomized Controlled Trial|
|Principal investigator||Eman M Khedr, Professor|
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