Overview

This trial is active, not recruiting.

Conditions human metabolomic responses to plant foods, blood pressure
Treatment low phytochemical diet(lpd), high phytochemical diet(hpd)
Sponsor National Health Research Institutes, Taiwan
Collaborator Tri-Service General Hospital
Start date December 2010
End date December 2013
Trial size 50 participants
Trial identifier NCT01600911, EC0991003

Summary

Vegetable is well known to prevent chronic disease,however, the mechanism of its nutrients and non-nutrients still remains to be discovered.We design a feeding study which provides plant foods to subjects one by another and monitoring metabolomic changes up to 7 hours.The goal of this study is to establish a protocol for documenting metabolomics response to plant foods and try to characterize plant foods in terms of their anti-hypertension potentials with metabolomic profiling information.

United States No locations recruiting
Other Countries No locations recruiting

Study Design

Intervention model single group assignment
Masking open label
Primary purpose treatment

Primary Outcomes

Measure
blood pressure
time frame: one day

Secondary Outcomes

Measure
metabolomic profile of serum and urine
time frame: one day

Eligibility Criteria

Male or female participants from 18 years up to 60 years old.

Inclusion Criteria: - Age :18-60 years - Body Mass Index :18.5-30(kg/m2) - Non-smoking,alcohol abusing,and other bad hobbies Exclusion Criteria: - With regular drug intake e.g. anti-hypertensive or antidiabetes drug or history of immune, hepatic and metabolic disease or other unsuitable disorders e.g. cancer. - unwilling to stop regular food supplement e.g. vitamins, herb - cannot cooperate with designed diet - History of urinary tract infection or antibiotic use within the previous 3 month

Additional Information

Official title Establish a Vegetable Signature Database From Human Metabolomics Responses
Principal investigator Wen-Harn Pan, Ph.D.
Trial information was received from ClinicalTrials.gov and was last updated in May 2012.
Information provided to ClinicalTrials.gov by National Health Research Institutes, Taiwan.