This trial is active, not recruiting.

Conditions death, carotid artery disease, cardiovascular disease, peripheral artery disease
Treatment lifestyle counseling
Sponsor Haukeland University Hospital
Start date September 2010
End date December 2015
Trial size 1062 participants
Trial identifier NCT01597453, 2010/74


NOR-SYS is a clinical research program about young ischemic stroke patients from 15 to 60 years. Patients, partners and the couple´s adult children who are at least 18 years old, are all invited to ultrasound examinations due to a standardized protocol.

Parents of patients and partners are invited to return their answers of standardized questionnaires about clinical ischemic events such as stroke, angina or myocardial infarction or peripheral artery disease.

Study inclusion time of patients and their families is 5 years. A biobank is build from samples from patients, partners and adult children. Clinical follow-ups for patients and partners are planned after 5, 10 and 15 years. Clinical follow-ups for adult children are planned after 10 and 20 years.


What do patients know about their parents clinical ischemic events? How much established pathology in arteries do we find by a standardized ultrasound protocol at the time of ischemic stroke at a young age? Differences concerning risk factors and ultrasound findings between patients and partners? Differences between children from families with several ischemic events among parents and grandparents vs. children from families without ischemic events? Biochemical markers related to ultrasound findings and artery disease.

United States No locations recruiting
Other countries No locations recruiting

Study Design

Intervention model single group assignment
Masking open label
Primary purpose diagnostic
lifestyle counseling NOR-SYS
Ultrasound examinations of carotid arteries, aorta abdominalis, femoral arteries and lifestyle counseling

Primary Outcomes

All cause mortality
time frame: 20 years

Secondary Outcomes

Arterial events (recurrent stroke or transitory ischemic attack, myocardial infarction or angina, peripheral artery disease
time frame: 20 years

Eligibility Criteria

Male or female participants from 15 years up to 60 years old.

Inclusion Criteria: - Documented ischemic stroke at age from 15 up to 60 years Exclusion Criteria: - Stroke as end-of-life event among patients with cancer or other life-threatening disease - Stroke caused by trauma

Additional Information

Official title NOR-SYS: The Norwegian Stroke in the Young Study Young Ischemic Stroke and Family Risk Factors
Principal investigator Ulrike Waje-Andreassen, MD, PhD
Description Equal examinations for patients, partners and adult children are: - Standardized questionnaires - Extracranial duplexsonography - Duplexsonography of the abdominal aorta - Duplexsonography of femoral arteries - Duplexsonography of epicardial, intrabdominal and subcutaneous fat - Peripheral ultrasound, Ankle-arm index - ECG - Blood pressure measurement - BMI and Waist-hip ratio - Blood samples
Trial information was received from ClinicalTrials.gov and was last updated in February 2016.
Information provided to ClinicalTrials.gov by Haukeland University Hospital.