This trial is active, not recruiting.

Conditions encephalopathy, hepatic, cerebrovascular disorders, liver failure
Treatment no interventions
Sponsor Johannes Gutenberg University Mainz
Start date January 2012
End date December 2017
Trial size 20 participants
Trial identifier NCT01597102, 837.041.10 III


The cerebrovascular autoregulation (AR) is impaired in patients with hepatic encephalopathy. Patients with the indication to liver transplantation mostly have mild to severe hepatic encephalopathy. Transplantation should recover the encephalopathy. The aim of the study is to investigate the AR during liver transplantation, with the questions if the AR is impaired at the beginning of surgery and if there are changes in AR. For follow up the AR will be measured at the first days after transplantation at the ICU.

United States No locations recruiting
Other Countries No locations recruiting

Study Design

Time perspective prospective
Patients with liver failure and liver transplantation
no interventions No intervention is planned in this study
No intervention is planned in this study

Primary Outcomes

Changes of cerebrovascular autoregulation during liver transplantation
time frame: During the surgery

Secondary Outcomes

Time course of cerebrovascular autoregulation after liver transplantation
time frame: First 4 days after transplantation

Eligibility Criteria

Male or female participants at least 18 years old.

Inclusion Criteria: - liver transplantation - age > 18 years Exclusion Criteria: - sepsis - preexisting cerebral diseases - traumatic brain injury - pregnancy

Additional Information

Official title Cerebrovascular Autoregulation During and After Liver Transplantation
Principal investigator Patrick Schramm, MD
Description The cerebrovascular autoregulation (AR) will be measured using transcranial doppler and calculating the index of autoregulation Mx. This measurement is continuous with online calculation. So, the possible changes over the whole time of surgery can be detected. Furthermore, the measurement of AR at the ICU will be performed daily at the same time over a measurement period of 60 Minutes and the time course of AR after liver transplantation will be described.
Trial information was received from ClinicalTrials.gov and was last updated in January 2013.
Information provided to ClinicalTrials.gov by Johannes Gutenberg University Mainz.