Efficacy Study of Ketamine for Postoperative Pain in Opioid Dependent Patients
This trial is active, not recruiting.
|Sponsor||Brigham and Women's Hospital|
|Start date||September 2008|
|End date||June 2011|
|Trial size||64 participants|
|Trial identifier||NCT01591382, 2008P001126|
Patients who are dependent on opioids often have poor pain relief after major surgery. This study tests the hypothesis that adding intravenous ketamine to a postoperative regimen of intravenous opioids for postoperative pain will improve pain relief in this subset of patients.
|Endpoint classification||efficacy study|
|Intervention model||single group assignment|
|Masking||double blind (subject, caregiver, investigator, outcomes assessor)|
time frame: Participants will be followed for the duration of hospital stay, an expected average of 3 days
Male or female participants at least 18 years old.
Inclusion Criteria: - Chronic pain > 6 months - Long term use of opioids - Major surgery Exclusion Criteria: - Use of regional anesthetic techniques - No need for IV PCA after surgery
|Official title||Hydromorphone PCA or Hydromorphone PCA With Ketamine for Acute Postoperative Pain Relief in Opioid-Dependent Chronic Pain Patients|
|Principal investigator||Srdjan S Nedeljkovic, M.D.|
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