Overview

This trial is active, not recruiting.

Condition patients undergoing coronary angiography
Sponsor University of Ioannina
Collaborator University Hospital, Ioannina
Start date November 2009
End date May 2013
Trial size 1000 participants
Trial identifier NCT01585948, UOICAD2010

Summary

In the present study the investigators will measure the extent of coronary artery disease via coronary angiography and the correlating risk factors.

United States No locations recruiting
Other Countries No locations recruiting

Study Design

Observational model case control
Time perspective cross-sectional
Arm
All patients undergoing coronary angiography who are diabetics.
All patients undergoing coronary angiography that are non-diabetics.
Diabetics and non-diabetics with or without known CV disease who are admitted in the Department of Cardiology in the University Hospital of Ioannina and the Catheterization Laboratory of 1st IKA Hospital in Athens and undergo coronary angiography for clinical purposes will be studied. The study will include subjects who 1) have suspected CAD and undergo a scheduled diagnostic angiogram for clinical reasons, and 2) are hospitalized because of an acute coronary syndrome and thus undergo diagnostic angiography (with or without previous history of CAD).

Primary Outcomes

Measure
The incidence and extent of coronary artery disease between diabetics and non-diabetic patients.
time frame: Up to four years on average.

Secondary Outcomes

Measure
The incidence and extent of coronary artery disease via coronary angiography scores and related biochemical and demographical risk factors.
time frame: Up to 4 years on average.
The incidence, extent and clinical manifestation of coronary artery disease and the circulating levels of hs-CRP, adipokines and RAGEs.
time frame: Up to 4 years on average.
TCF7L2 gene polymorphims and the incidence and extent of coronary artery disease.
time frame: Within a maximum period of 4 years.

Eligibility Criteria

Male or female participants from 18 years up to 90 years old.

Inclusion Criteria: - Any subject eligible for coronary angiography with or without known CV disease for clinical reasons. Exclusion Criteria: - Patients revascularized in the past, with either coronary artery bypass grafting or percutaneous coronary intervention, will be excluded from the study since it is not possible to describe the extent of CAD in these patients. - Moderate or severe aortic stenosis.

Additional Information

Official title The Role of Newer and Traditional Risk Factors in the Development, Extent and Manifestation of Coronary Artery Disease
Principal investigator Katerina Naka, Lecturer
Description In the present study the investigators will examine the risk factors determining the development, extent and the manifestation of coronary artery disease. The study will recruit patients undergoing coronary angiography for clinical purposes.
Trial information was received from ClinicalTrials.gov and was last updated in May 2016.
Information provided to ClinicalTrials.gov by University of Ioannina.