Overview

This trial is active, not recruiting.

Condition acute and chronic hepatic failure with developing coma
Sponsor The University of Texas Medical Branch, Galveston
Start date February 2012
End date December 2015
Trial size 20 participants
Trial identifier NCT01582087, 12-030

Summary

The purpose of this study is to understand mechanisms associated with the development of coma during hepatic failure. As of today, those mechanisms are not understood and it is difficult to intervene and prevent coma development which is often associated with mortality. Understanding the mechanism involved, may allow us to prevent coma and develop new therapies to treat this disease.

United States No locations recruiting
Other Countries No locations recruiting

Study Design

Observational model cohort
Time perspective retrospective
Arm
All patients presenting at University of Texas Medical Branch (UTMB) with acute and chronic hepatic failure and who are developing coma

Primary Outcomes

Measure
The relationship that exist between a liver undergoing chronic or acute degeneration and hepatic coma.
time frame: 8 weeks

Eligibility Criteria

Male or female participants at least 18 years old.

Inclusion Criteria: - Patients (male or female), 18 years or older hospitalized or seen at UTMB clinics for chronic or acute hepatic failure will be included in the study. Exclusion Criteria: - Patients (male or female), 18 years or older hospitalized or seen at UTMB clinics that do not have a diagnosis of chronic or acute hepatic failure

Additional Information

Official title Evaluation of Mechanisms Responsible for Coma in Patients Affected by Fulminant, Acute and Chronic Hepatic Failure
Principal investigator Luca Cicalese, MD
Trial information was received from ClinicalTrials.gov and was last updated in August 2015.
Information provided to ClinicalTrials.gov by The University of Texas Medical Branch, Galveston.