The Neurobiology of Expectancy and Pain Perception
This trial is active, not recruiting.
|Treatment||heat pain applied using tsa or cheps|
|Sponsor||Massachusetts General Hospital|
|Start date||June 2012|
|End date||June 2015|
|Trial size||40 participants|
|Trial identifier||NCT01575106, 2011P000663|
This study will use using fMRI (functional Magnetic Resonance Imaging) to elucidate how contextual learning/expectation relieves or aggravates pain experience in the same cohort of subjects and the same study session.
|Intervention model||single group assignment|
|Masking||single blind (subject)|
fMRI signal changes
time frame: One day
Subjective response to pain
time frame: 1to 3 weeks
Male or female participants from 21 years up to 50 years old.
Inclusion Criteria: - a) Healthy male and female adults aged 21-50 - b) No contraindications to fMRI scanning - c) Right handed Exclusion Criteria: - a) Current or past history of major medical, neurological, or psychiatric illness - b) Pregnancy or breast feeding, menopause, and irregular menstrual cycles (length of cycle must be within 26 to 32 days) - c) Claustrophobia - d) History of head trauma - e) History of impaired elimination - f) Instability of responses to experimental pain (see Study Procedures Section) - g) Use of psychotropic drugs, hormone treatments (including hormonal birth control) within 1 year - h) Non-fluent speaker of English
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