This trial is active, not recruiting.

Conditions acute mountain sickness, high altitude pulmonary edema, high altitude cerebral edema
Sponsor University Hospital, Grenoble
Start date July 2011
End date October 2011
Trial size 12 participants
Trial identifier NCT01565603, RCB 2011-A00071-40


Mechanisms underlying high-altitude intolerance as well as exercise performance limitation in hypoxia still remain to be fully understood. Recent data suggest that sleep disturbances on one hand and cerebral perturbations on teh other hand may be key mechanisms. The investigators evaluated 12 healthy subjects at sea level and at 4400 m of altitude for 7 days in order to better describe sleep and cerebral responses. The investigators hypothesized that sleep and cerebral disturbances play a critical role for the developement of acute mountain sickness and for exercise performance limitation during acute high-altitude exposure.

United States No locations recruiting
Other countries No locations recruiting

Study Design

Observational model case-only
Time perspective cross-sectional

Eligibility Criteria

Male participants from 18 years up to 50 years old.

Inclusion Criteria: - 18 to 50 yrs old - Male Exclusion Criteria: - Respiratory, cardiac, metabolic or neuromuscular diseases - History of severe acute mountain sickness

Additional Information

Official title Intolerance Mechanisms and Exercise Performance Limitation During a High Altitude Stay: Investigation of Sleep and Cerebral Responses
Trial information was received from ClinicalTrials.gov and was last updated in March 2012.
Information provided to ClinicalTrials.gov by University Hospital, Grenoble.