The Influence of Pressure Pain on [11C]Diprenorphine Binding Potentials
This trial is active, not recruiting.
|Sponsor||Massachusetts General Hospital|
|Start date||December 2011|
|End date||October 2012|
|Trial size||10 participants|
|Trial identifier||NCT01546155, 2011P0022171|
Healthy volunteers aged 21 to 50 are needed for a research study investigating whether pain will alter the binding properties of ([11C]diprenorphine), a molecule that can be used during brain imaging. Positron Emission Tomography (PET) and functional Magnetic Resonance (fMRI) imaging will be used in this study.
|Intervention model||single group assignment|
PET/MRI brain activation
time frame: one day
Male or female participants from 21 years up to 50 years old.
Inclusion Criteria: - Healthy male and female adults, 21 to 50 years of age - No contraindications to fMRI and PET scanning - Within 15% of ideal body mass index (BMI) Exclusion Criteria: - Current significant medical, neurological, or psychiatric illness as assessed by the Physician Investigators - Women who are pregnant or breast feeding, have gone through menopause, and/or have irregular menstrual cycles - Claustrophobia - History of head trauma - Instability of responses to experimental pain (See Study Procedure Section Part II) - History of asthma - Use of psychotropic drugs or hormone treatments (including hormonal birth control) within one year of date of consent - History of smoking - Routine exercise in excess of one hour per day and/or three times per week - Non-fluent English speaker
|Official title||The Influence of Pressure Pain on [11C]Diprenorphine Binding Potentials|
|Principal investigator||Jian Kong, MD (equiv), MS, MPH|
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