Overview

This trial is active, not recruiting.

Condition healthy controls
Treatment pet imaging
Sponsor Massachusetts General Hospital
Start date December 2011
End date October 2012
Trial size 10 participants
Trial identifier NCT01546155, 2011P0022171

Summary

Healthy volunteers aged 21 to 50 are needed for a research study investigating whether pain will alter the binding properties of ([11C]diprenorphine), a molecule that can be used during brain imaging. Positron Emission Tomography (PET) and functional Magnetic Resonance (fMRI) imaging will be used in this study.

United States No locations recruiting
Other Countries No locations recruiting

Study Design

Intervention model single group assignment
Masking open label
Arm
(Experimental)
pet imaging
Up to a 120 minute PET scan using [11C]diprenorphine as the radiotracer

Primary Outcomes

Measure
PET/MRI brain activation
time frame: one day

Eligibility Criteria

Male or female participants from 21 years up to 50 years old.

Inclusion Criteria: - Healthy male and female adults, 21 to 50 years of age - No contraindications to fMRI and PET scanning - Within 15% of ideal body mass index (BMI) Exclusion Criteria: - Current significant medical, neurological, or psychiatric illness as assessed by the Physician Investigators - Women who are pregnant or breast feeding, have gone through menopause, and/or have irregular menstrual cycles - Claustrophobia - History of head trauma - Instability of responses to experimental pain (See Study Procedure Section Part II) - History of asthma - Use of psychotropic drugs or hormone treatments (including hormonal birth control) within one year of date of consent - History of smoking - Routine exercise in excess of one hour per day and/or three times per week - Non-fluent English speaker

Additional Information

Official title The Influence of Pressure Pain on [11C]Diprenorphine Binding Potentials
Principal investigator Jian Kong, MD (equiv), MS, MPH
Trial information was received from ClinicalTrials.gov and was last updated in April 2015.
Information provided to ClinicalTrials.gov by Massachusetts General Hospital.