Overview

This trial has been completed.

Conditions fat excretion, energy excretion
Sponsor University of Copenhagen
Collaborator The Ministry of Science, Technology and Innovation, Denmark
Start date June 2010
End date August 2011
Trial size 158 participants
Trial identifier NCT01542164, H-B-2009-071

Summary

The overall purpose of this study is to examine the effect of calcium on fecal fat and energy excretion.

United States No locations recruiting
Other countries No locations recruiting

Study Design

Observational model other
Time perspective cross-sectional

Primary Outcomes

Measure
Total fat and energy excretion
time frame: 5 days

Secondary Outcomes

Measure
p-vitamin D
time frame: 1 day
p-PTH
time frame: 1 day
Selected genetic variations
time frame: 1 day
Blood lipids and cholesterol
time frame: 1 day
calcium excretion
time frame: 2 days
Gut micro flora
time frame: 1 day
NMR-spectroscopy based metabonomics profiling of urin
time frame: 1 day
blood pressure
time frame: 1 day

Eligibility Criteria

All participants from 18 years up to 50 years old.

Inclusion Criteria: - age between 18 - 50 years - healthy - weight stable within 4 months prior to the inclusion Exclusion Criteria: - pregnant or lactating - uses cholesterol lowering drugs - on diet - suffering from, now or previously, any gastrointestinal diseases - elite athletes - participation in other concomitant trial

Additional Information

Official title Calcium Intake and Fat Excretion - an Observational Study
Principal investigator Lesli H. Larsen, Ass. Prof.
Description Several reports have found inverse associations between calcium intake and body weight. Few intervention studies have shown that a high calcium diet resulted in a greater body weight loss than a low calcium diet. The mechanism is not clear, but one possible explanation is reduced absorption of fat in the gut, due to formation of insoluble calcium fatty acid soaps or binding of bile acids which impairs the formation of micelles. The aim of this study is to examined for an association between habitual calcium intake and fecal energy and fat excretion, concentrations of substrates involved in energy metabolism, blood pressure and body weight
Trial information was received from ClinicalTrials.gov and was last updated in February 2017.
Information provided to ClinicalTrials.gov by University of Copenhagen.