Overview

This trial is active, not recruiting.

Condition ovarian epithelial carcinoma
Treatment pd0332991
Phase phase 2
Target CDK4
Sponsor Jonsson Comprehensive Cancer Center
Start date December 2011
End date May 2017
Trial size 26 participants
Trial identifier NCT01536743, 11-003234

Summary

The purpose of this study is to obtain an estimate of the biochemical response rate as determined by CA125 response using the Gynecologic Cancer Intergroup (GCIG) response criteria of PD0332991 in patients with recurrent ovarian epithelial carcinoma. CA125 response is defined as ≥ 50% decrease from the baseline CA125 level and confirmed ≥ 21 days after initial evaluation (baseline is defined as the higher value of 2 pre-treatment CA125 assessments).

United States No locations recruiting
Other Countries No locations recruiting

Study Design

Endpoint classification safety/efficacy study
Intervention model single group assignment
Masking open label
Primary purpose treatment
Arm
(Experimental)
30 patients with recurrent ovarian epithelial carcinoma demonstrating Rb-proficiency and absent or low expression of p16 will be registered to receive PD0332991 once a day by mouth in the morning on an empty stomach. PD0332991 will be administered daily for 3 weeks followed by 1 week off treatment (28 day cycle).
pd0332991
30 patients with recurrent ovarian epithelial carcinoma demonstrating Rb-proficiency and absent or low expression of p16 will be registered to receive PD0332991 once a day by mouth in the morning on an empty stomach. PD0332991 will be administered daily for 3 weeks followed by 1 week off treatment (28 day cycle).

Primary Outcomes

Measure
Estimate biochemical response rate as determined by CA125 response using the Gynecologic Cancer Intergroup (GCIG) response criteria of PD0332991 in patients with recurrent ovarian epithelial carcinoma.
time frame: 4 weeks

Secondary Outcomes

Measure
Toxicity of PD0332991.
time frame: 4 weeks
Assess health-related quality of life (HRQL),
time frame: 4 weeks

Eligibility Criteria

Female participants at least 18 years old.

Inclusion Criteria 1. Histologically-confirmed ovarian epithelial (including fallopian tube and primary peritoneal) carcinoma. 2. 2. Baseline paraffin embedded tissue from the patient's primary diagnosis is requested before study enrolment and should be forwarded to the designated central laboratory where central assessment of Rb and p16 expression will be performed by using immunohistochemistry. In patients with measurable disease a tissue biopsy may be obtained by core biopsy and submitted to the designated central laboratory. 3. GCIG-defined CA125 progression and absence of disease upon imaging or small-volume asymptomatic disease upon imaging and who have progressed following one, two or three lines of chemotherapy for recurrent disease. 4. If patients have small-volume disease the current study will be restricted to patients with minimal ascites not causing abdominal distention/mesenteric thickening or not requiring paracentesis, or lesions ≤4 cm by spiral computed tomography [CT] or magnetic resonance imaging [MRI] at baseline. 5. Two pretreatment CA125 values (documented on two occasions taken at least one week apart) must be at least twice the upper limit of normal, or twice the nadir value if pretreatment CA125 values never normalized. 6. Patients with platinum-sensitive or platinum-resistant disease defined by recurrence or progression of disease > 6 months or ≤ than 6 months after completion of frontline platinum based chemotherapy. 7. ECOG performance status ≤ 1 and patients are to be ≥21 years of age. 8. Resolution of any toxic effects of prior therapy (except alopecia) to NCI CTCAE v.3.0 Grade ≤ 1 and to baseline laboratory values as defined in the inclusion criterion immediately below. 9. Adequate organ and bone marrow function as evidenced by: - hemoglobin ≥ 9.0 g/dL - absolute neutrophil count ≥ 1.5 x 109/L - platelet count ≥ 100 x 109/L - Renal function, as follows: - Serum creatinine ≤ 1.5 x the ULN or calculated creatinine clearance ≥ 40 mL/min - AST and ALT ≤ 2.5 x ULN - total bilirubin ≤ 1.5 x ULN unless increase is due to Gilbert's disease or similar syndrome involving slow conjugation of bilirubin, 10. Adequate coagulation parameters (within 21 days prior to registration), International Normalized Ratio (INR) ≤1.5; Activated ProThrombin Time (APTT) ≤ 1.5 x ULN. 11. Patient must be willing and able to comply with scheduled visits, treatment plans, laboratory tests, and other study procedures. 12. Informed consent must be obtained in writing for all patients prior to performing study/screening procedures and prior to registration into the study. Exclusion Criteria Patients presenting with any of the following will not be included in the study: 1. More than 4 prior chemotherapy regimens in the treatment of ovarian cancer. 2. Anticipation of immediate need for a major surgical procedure (e.g., impending bowel obstruction, gastrointestinal perforation) or radiation therapy during the trial. 3. Diagnosis of any second malignancy within the last 5 years, except for adequately treated basal cell or squamous cell skin cancer, or for in situ carcinoma of the cervix uteri or breast. 4. Treatment with chemotherapy, radiotherapy, surgery, blood products, or an investigational agent within 3 weeks of trial enrolment. 5. Any of the following within 6 months prior to trial registration: myocardial infarction, severe/unstable angina pectoris, coronary/peripheral artery bypass graft, NYHA class III or IV congestive heart failure, cerebrovascular accident or transient ischemic attack, pulmonary embolism, deep vein thrombosis, or other thromboembolic event. PD0332991 in Recurrent Ovarian Cancer 6. History of brain metastases, spinal cord compression, or carcinomatous meningitis. 7. Patient of child-bearing potential is evidently pregnant (eg, positive human chorionic gonadotropin test) or is breast feeding. A woman with child bearing potential is defined as not surgically sterile or being post-menopausal for less than 6 months. 8. Patient of child-bearing potential is not willing to use adequate contraceptive precautions. Adequate effective method of contraception are those which result in low failure rates, less than 1% per year, such as non-hormonal IUD, condoms, sexual abstinence or vasectomised partner. 9. Known active infection, or on antiretroviral therapy for HIV disease or positive test for chronic hepatitis B or C infection. 10. Mental condition rendering the patient unable to understand the nature, scope, and possible consequences of the trial. 11. Refusal or inability to give informed consent to participate in the trial. 12. Corrected QT (QTc) interval >470 msec. 13. If radiotherapy is required in a given patient, that patient should be withdrawn from the study. 14. Current use or anticipated need for: Food or drugs that are known strong CYP3A4 inhibitors (i.e. grapefruit juice, verapamil, ketoconazole, miconazole, itraconazole, posaconazole, erythromycin, clarithromycin, telithromycin, indinavir, saquinavir, ritonavir, nelfinavir, lopinavir, atazanavir, amprenavir, fosamprenavir, nefazodone, diltiazem, and delavirdine. 15. Other severe acute or chronic medical or psychiatric condition, or significant laboratory abnormality requiring further investigation that may cause undue risk for the patient's safety, inhibit protocol participation, or interfere with interpretation of trial results, and in the judgment of the investigator would make the patient inappropriate for entry into this trial.

Additional Information

Official title A Open Label Phase II Study of the Efficacy and Safety of PD0332991 a Selective Inhibitor of the Cyclin Dependent Kinases 4 and 6 in Patients With Recurrent Ovarian Cancer Demonstrating Rb-proficiency and Low p16 Expression
Principal investigator Gottfried Konecny, M.D.
Trial information was received from ClinicalTrials.gov and was last updated in August 2016.
Information provided to ClinicalTrials.gov by Jonsson Comprehensive Cancer Center.
Location data was received from the National Cancer Institute and was last updated in June 2016.