Repeated Challenge of Insufficient Sleep: Endothelial Effects
This trial is active, not recruiting.
|Condition||repeated short sleep schedule|
|Treatment||repeated cycles of short sleep|
|Sponsor||Beth Israel Deaconess Medical Center|
|Collaborator||National Heart, Lung, and Blood Institute (NHLBI)|
|Start date||August 2011|
|End date||December 2015|
|Trial size||52 participants|
|Trial identifier||NCT01523535, 2010P-000365, R01HL106782|
The 24-hour-a-day, 7-day a week, work-world arrived within our lifetimes, and is here to stay. Americans are working more and more, frequently at multiple jobs. The pattern of short sleep during the week followed by attempts to recover on the weekend is in common practice, but we know little of the associated health risks. What is the cost in terms of increasing known risk markers for cardiovascular disease, of repeated nights of insufficient sleep, and is this cost compounded with repetition, without adequate recovery? Evidence is accumulating to suggest that short sleep duration is linked to the development of metabolic and inflammation-associated diseases, such as cardiovascular disease. Mechanisms involved in the development of cardiovascular disease include impaired vascular function and inflammation. The current proposal is designed to investigate the effects of repeated periods of short nocturnal sleep duration in 4 cycles (each cycle consisting of 3 nights of 4 hours of sleep opportunity per night), and each cycle of short sleep followed by a single night of recovery sleep. Vascular reactivity will be assessed using brachial artery flow mediated dilation, and microcirculatory vasodilation will be assessed using perfusion imaging techniques. The dependence of IL-6 and sVCAM-1 as measured in peripheral circulation, on vascular function, will also be investigated.
|Intervention model||parallel assignment|
|Primary purpose||basic science|
time frame: 22 days
time frame: 22 days
Male or female participants from 25 years up to 55 years old.
Inclusion Criteria: - Healthy volunteers - Regular sleep-wake schedule Exclusion Criteria: - Diseases or medical conditions, including sleep disorders - Current smoking - Pregnant or nursing - Recent time zone travel or shift work - Regular medication use - High blood pressure
|Official title||Repeated Challenge of Insufficient Sleep: Effects on Endothelial Function|
|Principal investigator||Janet M Mullington, Ph.D.|
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