This trial is active, not recruiting.

Conditions burns, sepsis
Treatment continuous renal replacement therapy
Sponsor Southwest Hospital, China
Start date December 2011
End date December 2013
Trial size 60 participants
Trial identifier NCT01501097, SWHCBS01


The purpose of this study is to determine if early application of CRRT will result in an improvement of clinical outcomes of burn patients during the early phase of sepsis

United States No locations recruiting
Other Countries No locations recruiting

Study Design

Allocation randomized
Endpoint classification efficacy study
Intervention model parallel assignment
Masking open label
Primary purpose treatment
(No Intervention)
continuous renal replacement therapy
Patients will be randomized to either arm :early HV-crrt(50ml/kg/h) or Control group
continuous renal replacement therapy
Patients will be randomized to either arm :early HV-crrt(50ml/kg/h) or Control group

Primary Outcomes

Changes in serum cytokine concentrations and clearance
time frame: 96 hours

Secondary Outcomes

28 and 90 days survival
time frame: 90 days

Eligibility Criteria

Male or female participants from 18 years up to 70 years old.

Inclusion Criteria: - patients with documented sepsis - clinically identified focus of infection associated with at least 2 SIRS -criteria and one or more sepsis-induced organ failures within the 24 hours -prior to inclusion - age 18 to 70 years - severe burned patients with 50% < TBSA < 85% Exclusion Criteria: - cirrhosis child class C - too high APACHE II & SOFA score at admission - age over 70 years - were presence of a malignant tumor, chronic renal insufficiency (serum creatinine > 133 µmol/L), moribund state, receiving immunosuppressive therapy or receiving any kind of renal replacement therapy before randomization

Additional Information

Official title A Randomized Controlled Trial on the Impact of Early Application of CRRT on the Outcomes of Burn Patients With Early Phase of Sepsis
Description The impact of Continuous Renal Replacement Therapy (CRRT) on the outcomes of patients with sepsis is controversial, and there is no consensus for the timing and dose of CRRT may improve the outcomes. The purpose of this prospective randomized study is to assess the effect of different CRRT intensity (25ml/kg/h or 50ml/kg/h) on the outcomes of burn patients with early phase of sepsis
Trial information was received from ClinicalTrials.gov and was last updated in December 2011.
Information provided to ClinicalTrials.gov by Southwest Hospital, China.