This trial is active, not recruiting.

Condition actinic keratosis
Treatments ablative co2 laser therapy, photodynamic therapy
Sponsor Ruhr University of Bochum
Start date March 2011
End date December 2011
Trial size 21 participants
Trial identifier NCT01481155, PDT vs. CO2


The purpose of this study is to determine whether photodynamic therapy or CO2 laser therapy is superior in the treatment of actinic keratoses with respect to efficacy and side effects.

United States No locations recruiting
Other Countries No locations recruiting

Study Design

Endpoint classification efficacy study
Intervention model single group assignment
Masking single blind (investigator)
Primary purpose treatment

Primary Outcomes

Number of actinic keratoses 3 months after treatment
time frame: 3 months

Secondary Outcomes

Histologic features
time frame: 1 month after therapy
Epidermal thickness in optical coherence tomography
time frame: 1 month after therapy

Eligibility Criteria

Male or female participants at least 18 years old.

Inclusion Criteria: - men and women with clinical and histological diagnosed, symmetrical distributed actinic keratoses - at least 2 actinic keratoses, on each of both treatment areas at least one - Patients must be 18 years or older. Exclusion Criteria: - Age 17 years or younger - lack of patient's informed consent for any of the two treatments - contraindication for Co2 therapy or for photodynamic therapy - skin infection in the treatment area

Additional Information

Official title Prospective, Single-center, Investigator-blinded, Randomized, Half-side, Comparative Study of Photodynamic Therapy vs. CO2 Laser Therapy in Treatment of Actinic Keratoses
Description Ablative laser therapy and photodynamic therapy are widely used and accepted therapeutic methods to treat multiple actinic keratoses, yet comparative studies are rare. The purpose of this study is to compare both treatments intraindividually with respect to treatment efficacy and side effects.
Trial information was received from ClinicalTrials.gov and was last updated in December 2011.
Information provided to ClinicalTrials.gov by Ruhr University of Bochum.