Effects of Aerobic and Resistance Training on Accumulation of Old, Modified Proteins in Young and Older Adults
This trial is active, not recruiting.
|Treatments||high intensity aerobic exercise, resistance exercise training, combined|
|Start date||November 2011|
|End date||April 2017|
|Trial size||75 participants|
|Trial identifier||NCT01477164, 10-005853|
Muscle proteins accumulate damage during aging and leads to the loss of muscle mass and function in older people. Exercise can increase the making of new proteins and removal of older proteins, but it is not known if the effect changes with aging or type of exercise. The investigators will determine the ability for endurance, resistance, or a combination of exercise training to remove older-damaged proteins and make newer-functional muscle proteins in groups of younger and older people. The investigators will particularly study protein that are involved with energy production (mitochondrial proteins) and force production (contractile proteins).
Hypothesis 1: Older people will have greater accumulation of damaged proteins than younger people.
Hypothesis 2: Aerobic exercise will decrease the accumulation of damaged forms of contractile and mitochondrial proteins in younger and older people.
Hypothesis 3: Resistance exercise will decrease the accumulation of damaged forms of contractile proteins in younger and older people.
|Intervention model||parallel assignment|
|Primary purpose||basic science|
Skeletal muscle protein synthesis rate
time frame: Approximately 14 weeks for the endurance or resistance training groups and approximately 28 weeks for the combined group
Male or female participants from 18 years up to 80 years old.
Inclusion Criteria: - Healthy - 18 to 30 years or 65 to 80 years old - Male and female Exclusion Criteria: - Regular exercise program - Smoking - Metabolic disease (diabetes, cardiovascular disease, cancer, thyroid disorders) - Pregnancy - Inability to exercise - Overweight or obesity - Drugs known to impair metabolic function (statin, beta-blocker, anti-inflammatory) - Allergies to lidocaine
|Official title||Effects of Aerobic and Resistance Training on Accumulation of Old, Modified Proteins in Young and Older Adults|
|Principal investigator||K. Sreekumaran Nair, M.D., Ph.D.|
|Description||The loss of muscle mass and function with age leads to high social and economic costs. Lifestyle interventions that can help maintain muscle mass and function can be beneficial to improve health and decrease the costs associated with loss of independence in the elderly. Muscle proteins accumulate damage during aging, which is suggested to lead to loss of function. The biological processes that remove damaged proteins and synthesis new proteins appear to be decreased with aging. Exercise is known to increase the processes that remove older and synthesis newer muscle proteins and may be an effect lifestyle intervention to improve muscle quality and function. Additionally, specific types of proteins appear to decay with age including contractile and mitochondrial proteins. Different types of exercise training can increase the making of specific proteins. The investigators will examine the ability for aerobic and resistance training to increase the quality of mitochondrial and contractile proteins between younger and older people.|
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