Overview

This trial is active, not recruiting.

Condition specific phobia
Treatments d-cycloserine, exposure therapy, placebo
Sponsor Hartford Hospital
Start date July 2010
End date July 2011
Trial size 20 participants
Trial identifier NCT01450306, NAVE003220HU

Summary

The aim of the present study is to determine whether people receiving d-cycloserine and exposure therapy show different brain reactions to symptom provocation compared to people receiving placebo and exposure therapy.

United States No locations recruiting
Other Countries No locations recruiting

Study Design

Allocation randomized
Endpoint classification efficacy study
Intervention model parallel assignment
Masking double blind (subject, caregiver, outcomes assessor)
Primary purpose treatment
Arm
(Experimental)
d-cycloserine
50 mg d-cycloserine, oral, 1 dose
exposure therapy
Single session graded in vivo exposure therapy, 60-180 minutes
(Placebo Comparator)
exposure therapy
Single session graded in vivo exposure therapy, 60-180 minutes
placebo

Primary Outcomes

Measure
Change in blood oxygen level dependent (BOLD) signal in several brain regions of interest
time frame: 2 weeks

Secondary Outcomes

Measure
Snake Questionnaire (SNAQ) [Klorman R, Weerts TC, Hastings JE, Melamed BG, Lang PJ. Psychometric description of some specific fear questionnaires. Behavior Therapy. 1974;5:401-409.]
time frame: 2 weeks
Clinician's Global Impression (CGI) [Guy W. Assessment manual for psychopharmacology. Washington, DC: U.S. Government Printing Office; 1976.]
time frame: 2 weeks

Eligibility Criteria

Male or female participants at least 18 years old.

Inclusion Criteria: - Primary diagnosis of specific phobia (snakes) Exclusion Criteria: - History of psychosis, obsessive-compulsive disorder, or mania - Recent substance abuse or suicidality - Previous receipt of study treatments

Additional Information

Official title Exposure, D-cycloserine Enhancement, and fMRI in Snake Phobics
Principal investigator David Tolin, PhD
Trial information was received from ClinicalTrials.gov and was last updated in October 2011.
Information provided to ClinicalTrials.gov by Hartford Hospital.