Stereotactic Radiation in Vestibular Schwannoma
This trial is active, not recruiting.
|Treatments||stereotactic radiotherapy, stereotactic radiosurgery|
|Start date||October 2011|
|End date||October 2013|
|Trial size||200 participants|
|Trial identifier||NCT01449604, RAMART0111|
The purpose of this study is to determine whether stereotactic radiosurgery (SRS)and stereotactic radiotherapy (SRT)are effective in the treatment of vestibular schwannoma (VS).
|Endpoint classification||efficacy study|
|Intervention model||parallel assignment|
|Masking||single blind (outcomes assessor)|
time frame: two year
number of participant with adverse event
time frame: 2 year
time frame: 2 year
Male or female participants from 18 years up to 80 years old.
Inclusion Criteria: - vestibular schwannoma tumor size not more than 3 cm. Exclusion Criteria: - NF 2 patient - underlying cerebrovascular disease - tumor compress and efface brain stem ( Koos 4)
|Official title||Randomized Comparison of Steretotactic Radiosurgery and Hypofractionated Steretotactic Radiotherapy in the Treatment of Vestibular Schwannoma|
|Principal investigator||Putipun Puataweepong, M.D.|
|Description||Vestibular schwannomas (VSs) are slow-growing tumors of the myelin-forming cells that cover cranial nerve VIII.The treatment options for patients with VSs include active observation, surgical management, and radiotherapy. However, the optimal treatment choice remain controversial. Over the past 10 years, there has been rapid progress in the application of stereotactic radiotherapy to the treatment of VSs. The stereotactic radiotherapy program includes single fraction radiosurgery (SRS) and hypofraction stereotactic radiotherapy (HSRT) are commonly used for VSs treatment. Since SRS and SRT techniques differ significantly enough to raise questions of therapeutic advantage and until now, there is no prospective, randomized study comparing the outcomes for patients treated using both radiotherapy techniques. We designed the first prospective randomized protocol to compare SRS and SRT for answer this question.|
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