Prevention of Postoperative Pneumonia (POPP)
This trial is active, not recruiting.
|Conditions||post-operative pneumonia, lung cancer, esophageal cancer|
|Treatment||intensive brushing regimen|
|Phase||phase 2/phase 3|
|Sponsor||Washington University School of Medicine|
|Start date||September 2011|
|End date||June 2016|
|Trial size||330 participants|
|Trial identifier||NCT01446874, 201106336|
Postoperative pneumonia is a major complication in patients undergoing thoracic surgery. It leads to considerable morbidity and contributes to perioperative morbidity. There is evidence in literature that supports the use of strategies for improved oral hygiene and specialized endotracheal tubes in preventing ventilator associated pneumonia (VAP) in mechanically ventilated patients. This study aims at utilizing a combination of these interventions in the perioperative period in patients undergoing planned thoracic surgical procedures.
|United States||No locations recruiting|
|Other Countries||No locations recruiting|
|Intervention model||single group assignment|
Incidence of postoperative pneumonia in the two groups: lung cancer resection patients and esophageal resection patients
Compliance with preoperative brushing and mouthwash protocol
Male or female participants at least 18 years old.
Inclusion Criteria: 1. Patients with lung lesions undergoing anatomic resection (lobectomy/segmentectomy/bilobectomy/pulmonary sleeve resection/pneumonectomy) 2. Patients with poor lung function (FEV1% <50% or DLCO<50% predicted or home oxygen requirement) and lung lesions undergoing non-anatomic lung resection (i.e. wedge resection). 3. Patients undergoing esophageal resection. Exclusion Criteria: 1. Patients with ongoing symptomatic dental infections. 2. Patients with recent/ongoing pneumonia (<15 days from initial surgical patient evaluation). 3. Patients who've received a therapeutic course of antibiotics within 15 days prior to thoracic surgery. 4. Patients with a preexisting tracheostomy. 5. Age<18
|Official title||Prevention of Postoperative Pneumonia (POPP Study: A Study to Evaluate the Use of a Prophylactic Clinical Strategy to Prevent Postoperative Pneumonia in Patients Undergoing Thoracic Surgery|
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