DANish Study of Optimal Acute Treatment of Patients With ST-elevation Myocardial Infarction
This trial is active, not recruiting.
|Condition||st segment elevation myocardial infarction|
|Treatments||conventional primary pci, ischemic postconditioning., deferred stenting in primary pci.|
|Start date||April 2011|
|End date||February 2016|
|Trial size||2000 participants|
|Trial identifier||NCT01435408, DANAMI-3|
This study focuses on Cardioprotective strategies.
|United States||No locations recruiting|
|Other countries||No locations recruiting|
|Aalborg, Denmark||Department of Cardiology, Aalborg University Hospital||no longer recruiting|
|Aarhus, Denmark||Department of Cardiology, Skejby University Hospital||no longer recruiting|
|Copenhagen, Denmark||The Heart Center, Rigshospitalet, University of Copenhagen||no longer recruiting|
|Hellerup, Denmark||Department of Cardiology, Gentofte University Hospital||no longer recruiting|
|Odense, Denmark||Department of Cardiology, Odense University Hospital||no longer recruiting|
|Endpoint classification||efficacy study|
|Intervention model||parallel assignment|
|Masking||single blind (subject)|
All cause mortality, heart failure (postconditioning)
time frame: 2 years
Infarct size in relation to area at risk as determined by MRI after 3 month
time frame: 3 month
All cause mortality, myocardial infarction, repeat revascularisation and occurrence of definite stent thrombosis according to ARC definition within 1 year (deferred stent strategy)
time frame: 1 year
Male or female participants of any age.
Inclusion Criteria: - Age ≥ 18 years. - Acute onset of chest pain of < 12 hours' duration. - ST-segment elevation ≥ 0.1 mV in ≥ 2 contiguous leads, signs of a true posterior infarction or documented newly developed left bundle branch block. Culprit lesion in a major native vessel. Exclusion Criteria: - Pregnancy. - Known intolerance of ASA, clopidogrel, heparin or contrast. - Inability to understand information or to provide informed consent. - Haemorrhagic diathesis or known coagulopathy. - Stent thrombosis.
|Official title||A Randomised Comparison of the Clinical Outcome After Postconditioning or Deferred Stent Implantation Versus Conventional Treatment|
|Principal investigator||Lars Koeber, Prof., DMSci|
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