Improving Intermediate Risk Management. MARK Study
This trial is active, not recruiting.
|Conditions||myocardial infarction, angina pectoris, stroke, peripheral arterial disease|
|Sponsor||Jordi Gol i Gurina Foundation|
|Collaborator||Preventive Services and Health Promotion Research Network|
|Start date||July 2011|
|End date||December 2013|
|Trial size||2495 participants|
|Trial identifier||NCT01428934, PI10/01088|
Cardiovascular risk functions fail to identify more than 50% of patients who develop cardiovascular disease. This is especially evident in the intermediate-risk patients in which clinical management becomes difficult. The purpose of this study is to analyze if ankle-brachial index (ABI), measures of arterial stiffness, postprandial glucose, glycosylated hemoglobin, self-measured blood pressure and presence of comorbidity are independently associated to incidence of vascular events and whether they can improve the predictive capacity of current risk equations in the intermediate-risk population.
|United States||No locations recruiting|
|Other Countries||No locations recruiting|
time frame: 10 years
Male or female participants from 35 years up to 74 years old.
Inclusion Criteria: - Population aged 35 to 74 which have an intermediate cardiovascular risk. Exclusion Criteria: - Terminal illness or institutionalization at the appointment time - Personal history of atherosclerotic disease
|Official title||Improving Intermediate Risk Management. MARK Study|
|Principal investigator||Rafel Ramos|
|Description||Primary prevention of cardiovascular diseases is a priority in public health policy of developed and developing countries. The fundamental strategy consists in identifying people in a high risk situation in which preventive measures are effective and efficient. However, specificity and sensitivity of risk equations are modest, which means that approximately 50% of the patients who are likely to develop a vascular event and would benefit from preventive measures are not considered at high risk. While 30% of the subjects considered at risk don't really benefit from preventive measures. Moreover, decisions which imply thousands of people and can determine drug treatment indications are taken every day in primary care centers. These decisions are based mostly on the result of estimations about the probability to develop a vascular disease in 10 years. Improvement of these predictions in our country will have an immediate, clinical and welfare impact and a short term public health effect. The purpose of this study is to analyze if ankle-brachial index (ABI), measures of arterial stiffness, postprandial glucose, glycosylated hemoglobin, self-measured blood pressure and presence of comorbidity are independently associated to incidence of vascular events and whether they can improve the predictive capacity of current risk equations in the intermediate-risk population.|
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