This trial is active, not recruiting.

Conditions acute coronary syndrome, acute chest pain
Treatment cardiac ct
Sponsor Erasmus Medical Center
Start date July 2011
End date February 2014
Trial size 500 participants
Trial identifier NCT01413282, BEACON-11


The purpose of this study is to determine whether cardiac CT can improve triage of acute chest pain patients in the emergency department.

United States No locations recruiting
Other countries No locations recruiting

Study Design

Allocation randomized
Endpoint classification efficacy study
Intervention model parallel assignment
Masking open label
Primary purpose diagnostic
(Active Comparator)
Triage based on cardiac CT results.
cardiac ct
Calcium scan and CT coronary angiography
(No Intervention)
Standard diagnostic management according to the European guidelines.

Primary Outcomes

Successful discharge rate
time frame: 30 days
Diagnostic yield of invasive angiography
time frame: 30 days

Secondary Outcomes

Successful discharge rate for all adverse events
time frame: 30 days
Major adverse events
time frame: 6 months
Acute coronary syndrome
time frame: Index hospital visit
Missed myocardial infarctions
time frame: 2 days
Duration of hospital stay
time frame: Index hospital visit
Direct medical cost
time frame: 30 days
Radiation exposure
time frame: 6 months
Renal function
time frame: 2 days

Eligibility Criteria

Male or female participants from 30 years up to 80 years old.

Inclusion Criteria: - Acute chest pain or equivalent - Patients older than 30 years - Males < 75 years and Females < 80 years Exclusion Criteria: - STEMI - Troponin > 0.1 - History of known myocardial infarction, PCI or CABG - Pregnancy - Contrast allergy - Renal disfunction - No informed consent possible - No follow-up possible

Additional Information

Official title Better Evaluation of Acute Chest Pain With Computed Tomography Angiography - A Randomized Controlled Trial
Description Myocardial infarction remains one of the most important causes of death and disability. Therefore it is important that individuals with acute chest pain are accurately assessed without delaying appropriate treatment. Acute coronary syndrome is only one cause for sudden chest pain, which is a very common complaint in the ER. Other life threatening causes such as pulmonary embolism and aortic dissection may also be the cause, although most chest discomfort has a benign reason (musculoskeletal, hyperventilation, oesophageal reflux, etc). The current work-up of suspected acute coronary syndrome, based on presentation, symptoms, ECG and biomarkers, is not efficient and results in unnecessary diagnostics and hospital admissions, as well as errors or delayed diagnoses, in a substantial number of patients. Computed tomography angiography (CTA) images atherosclerosis, coronary obstruction as well as myocardial hypoperfusion. We hypothesize that early use of CTA is of incremental value and allows for accurate and immediate triage of patients with acute chest pain.
Trial information was received from ClinicalTrials.gov and was last updated in February 2014.
Information provided to ClinicalTrials.gov by Erasmus Medical Center.