Effect of Beta-Glucan on Cholesterol Lowering
This trial is active, not recruiting.
|Treatments||control, 3g lmw beta-glucan, 5g lmw beta-glucan, 3g hmw beta-glucan|
|Sponsor||University of Manitoba|
|Collaborator||Agriculture and Agri-Food Canada|
|Start date||November 2010|
|End date||March 2014|
|Trial size||45 participants|
|Trial identifier||NCT01408719, B2010:216|
The purpose of this project is to study how the soluble fibre component of barley foods lower blood cholesterol levels when these foods are incorporated into a healthy diet.
|Endpoint classification||efficacy study|
|Intervention model||crossover assignment|
|Masking||single blind (subject)|
time frame: 35 days
Male or female participants from 18 years up to 78 years old.
Inclusion Criteria: - BMI 20-40 kg/m2 - Fasting cholesterol levels of 5.0-8.0 mmol/L - Fasting serum LDL cholesterol levels of 2.7-5.0 mmol/L Exclusion Criteria: - Pregnant or lactating - Taking lipid lowering medication or nutritional supplements that affect blood lipids - Not deemed healthy by study physician
|Official title||Effect of Beta-Glucan Molecular Weight and Viscosity on the Mechanism of Cholesterol Lowering in Humans|
|Principal investigator||Nancy Ames, PhD|
|Description||This study consists of four dietary phases which are separated by at least 21 days wash-out period. While participating in a treatment phase, the Richardson Centre will provide subjects with all meals for the 35 day period. Breakfast meals will be consumed under the supervision of the research staff and lunch, dinner and snacks will be provided to take home in take-out packaging. While subjects are on the wash-out period they will return to their normal diet. The meals are on a 7 day rotating schedule that reflect an average Canadian diet.|
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