Investigating Motor Cortex Processing for Pain Modulation
This trial has been terminated.
|Treatments||motor learning, somatosensory learning, observational task, mental imagery, transcranial direct current stimulation|
|Sponsor||Spaulding Rehabilitation Hospital|
|Start date||September 2010|
|End date||April 2014|
|Trial size||115 participants|
|Trial identifier||NCT01404039, 2010-p-001256|
The purpose of this study is to investigate the effects of different types of interventions (motor learning, somatosensory learning, observation task, mental imagery and tDCS) on the perception of pain and motor cortex excitability in healthy male subjects. This is an exploratory study of healthy subjects only.
|Intervention model||parallel assignment|
|Intervention model description||there are 5 experiments: motor learning (3 groups, crossover), sensory learning (4 groups, parallel), observational task (2 groups, parallel), mental imagery (2 groups, parallel), and tdcs over the motor cortex (2 groups, crossover). please note that the tdcs experiment has never been conducted.|
|Primary purpose||basic science|
|Masking||investigator, outcomes assessor|
Change in Motor Cortex Excitability MEP Amplitude
time frame: after each intervention
Male participants from 18 years up to 64 years old.
Inclusion Criteria 1. Provide informed consent to participate in the study 2. 18 to 64 years old 3. No presence of rheumatologic disease as self reported 4. No clinically significant or unstable medical or psychiatric disorder as self reported 5. No history of alcohol or substance abuse within the last 6 months as self reported 6. No neuropsychiatric co-morbidity as self reported 7. No Contraindications to single pulse TMS (TMS will be used to measure cortical excitability) - history of seizures - unexplained loss of consciousness - metal in the head - frequent or severe headaches or neck pain - implanted brain medical devices 8. No Contraindications to tDCS - metal in the head - implanted brain medical devices
|Official title||Investigating Motor Cortex Processing for Pain Modulation|
|Principal investigator||Felipe Fregni, MD, PhD, MPH|
|Description||There are 5 experiments: Exp1: motor learning (3 groups, crossover) - motor leaning with and without visual feedback and a control group. Exp2: sensory learning (4 groups, parallel) - sensory learning with and without feedback, an simple activation task and a control group. Exp3: observational task (2 groups, parallel) - an motor observational task and a control group. Exp4: mental imagery (2 groups, parallel) - a motor mental imagery and a control group. Exp5: tDCS over the motor cortex (2 groups, crossover) - active and sham tDCS. Note that this study has never been completed.|
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