The Telomere System in Cord Blood and in the Placenta in High Risk Pregnancies
This trial is active, not recruiting.
|Conditions||telomere length, mechanisms of telomter homeostasis, high risk pregnancies|
|Sponsor||Meir Medical Center|
|Start date||June 2011|
|End date||June 2015|
|Trial size||100 participants|
|Trial identifier||NCT01384136, 036-2011 MMC|
The telomere system stabilizes the chromosomes. Telomeres are shortened during senescence, in cases of genetic instability and secondary to stress.
The investigators aim is to study the telomere system in cord blood and in the placenta immediately after the delivery in pregnancies defined as high risk pregnancies following sterss events such as placental insufficiency, preeclampsia, diabetes.
The investigators intend to compare the telomere system in maternal blood to cord blood and to placental biopsies and to study the influence of different stressogenes on this system.
|Observational model||case control|
Female participants from 18 years up to 45 years old.
Inclusion Criteria: - Third trimester post delivery - Intrauterine growth restriction - Preeclampsia - Diabetes - Control - low risk normal pregnancies Exclusion Criteria: - Patients who do not want to participate - Known HIV or Hepatitis
|Official title||The Telomere System in Cord Blood and in the Placenta in High Risk Pregnancies|
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