This trial is active, not recruiting.

Conditions telomere length, mechanisms of telomter homeostasis, high risk pregnancies
Sponsor Meir Medical Center
Start date June 2011
End date June 2015
Trial size 100 participants
Trial identifier NCT01384136, 036-2011 MMC


The telomere system stabilizes the chromosomes. Telomeres are shortened during senescence, in cases of genetic instability and secondary to stress.

The investigators aim is to study the telomere system in cord blood and in the placenta immediately after the delivery in pregnancies defined as high risk pregnancies following sterss events such as placental insufficiency, preeclampsia, diabetes.

The investigators intend to compare the telomere system in maternal blood to cord blood and to placental biopsies and to study the influence of different stressogenes on this system.

United States No locations recruiting
Other countries No locations recruiting

Study Design

Observational model case control
Time perspective cross-sectional

Eligibility Criteria

Female participants from 18 years up to 45 years old.

Inclusion Criteria: - Third trimester post delivery - Intrauterine growth restriction - Preeclampsia - Diabetes - Control - low risk normal pregnancies Exclusion Criteria: - Patients who do not want to participate - Known HIV or Hepatitis

Additional Information

Official title The Telomere System in Cord Blood and in the Placenta in High Risk Pregnancies
Trial information was received from ClinicalTrials.gov and was last updated in June 2011.
Information provided to ClinicalTrials.gov by Meir Medical Center.