Permissive Hypercapnia and Brain Development in Premature Infants
This trial is active, not recruiting.
|Sponsor||Arkansas Children's Hospital Research Institute|
|Start date||May 2011|
|End date||May 2016|
|Trial size||40 participants|
|Trial identifier||NCT01361360, Thrasher|
In the US, every year approximately 30,000 infants are born very prematurely, with birth weight less than 1000 grams. These infants usually require ventilators to help them breath normally during the first few weeks of life. Although the ventilator is lifesaving, it can also injure the very fragile lungs of these infants. Thus, a ventilation strategy, called permissive hypercapnia (high carbon dioxide), is widely used to prevent lung injury. Importantly, there is new research showing that high carbon dioxide may cause brain injury. In our proposed research, we will use magnetic resonance imaging methods to evaluate the brain in 40 very premature infants at term−equivalent age (Half of them had permissive hypercapnia ventilation, the other half did not) to see if permissive hypercapnia has adverse effect on brain development.
|Observational model||case control|
time frame: 0
Male or female participants from 3 months up to 5 months old.
- Premature infants with birth weight 401-1000 g
- Those with complex congenital anomalies, central nervous system malformations, chromosomal abnormalities, or hydrops fetalis
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