Mechanism-based Choice of Therapy for Neuropathic Pain
This trial is active, not recruiting.
|Sponsor||Rambam Health Care Campus|
|Start date||April 2008|
|End date||April 2012|
|Trial size||50 participants|
|Trial identifier||NCT01359514, PostOperativePain05CTIL|
Mechanism-based choice of therapy for neuropathic pain:
Can treatments success in neuropathic post-operative pain be coupled to psychophysical pain modulation profile?
|Intervention model||parallel assignment|
|Masking||double blind (subject, caregiver, investigator)|
time frame: One year
Male or female participants from 18 years up to 75 years old.
Inclusion Criteria: - patients planned for thoracotomy Exclusion Criteria: - age below 18 and above 75 years - patients with psychiatric or cognitive dysfunction precluding use of psychophysics - those who cannot communicate in Hebrew - patients with existing thoracic or other current chronic pain
|Official title||Mechanism-based Choice of Therapy for Neuropathic Pain: Can Treatments Success in Neuropathic Post-operative Pain be Coupled to Psychophysical Pain Modulation Profile?|
|Principal investigator||David Yarnitsky, Professor|
|Description||Neuropathic or idiopathic pain patients will be assessed with the variety of pain tests including the conditioned pain modulation (CPM) and temporal summation (TS). Then, they will be offered on the double-blind design a several weeks treatment with either pregabalin or duloxetine. Patients will be followed-up weekly by phone for their pain relief and will be re-assessed in the lab toward the end of the treatment. The investigators suggest that patients with less-efficient CPM (deficient pain inhibition) will "earn" more pain relief from the treatment with duloxetine, while the patients with the enhanced pain summation will response better to pregabalin.|
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