This trial is active, not recruiting.

Condition acute myocardial infarction
Sponsor University College, London
Collaborator NICOR/MINAP, the United Kingdom
Start date March 2011
End date December 2014
Trial size 370000 participants
Trial identifier NCT01359033, FP7-EIS-WP7-MINAP


The study aims to investigate the differences in survival trajectories and hospital variability in myocardial infarction (MI) mortality rates in the UK and Sweden.

United States No locations recruiting
Other Countries No locations recruiting

Study Design

Observational model cohort
Time perspective retrospective
The Myocardial Ischaemia National Audit Project (MINAP) was established in 1999, in response to the national service framework (NSF) for coronary heart disease, to examine the quality of management of heart attacks (myocardial infarction) in hospitals in England and Wales.
The Register of Information and Knowledge About Swedish Heart Intensive Care Admissions (RIKS-HIA) has been established to record clinical and treatment information for all patients admitted to the coronary care units in Sweden from 1995.

Primary Outcomes

30-day mortality
time frame: 30-day

Secondary Outcomes

1-year mortality
time frame: 1 year

Eligibility Criteria

Male or female participants at least 30 years old.

Inclusion Criteria: - Patients aged above 30 years old who had hospital admission for acute myocardial infarction. - Admission period ranged from 1st January, 2004 to 31th December, 2008. Exclusion Criteria: - Patients with missing data in the admission time and/or primary outcomes.

Additional Information

Official title Compare the Patient Risk and Between-hospital Variation in Myocardial Infarction Mortality in the United Kingdom and Sweden
Principal investigator Sheng-Chia Chung, Ph.D
Description Limited evidence is available in comparing hospital level care and reference mortality risks between countries, due to the scarce availability of nationwide coronary heart disease data. The demographics and medical expenditure percentage are comparable in the United Kingdom and Sweden; however, the in-hospital case-fatality rates within 30 days after admission for acute myocardial infarction was greater in the UK than Sweden (6.3% versus 2.9%)(OECD, 2009). To investigate the discrepancy, the current study aims to compare the mortality risk differences and associated explanatory factors between the two countries. Results of the study can contribute to myocardial infarction care implementation in the UK and Sweden. The UK Myocardial Ischaemia National Audit Project (MINAP)and Register of Information and Knowledge about Swedish Heart Intensive care Admissions (RIKS-HIA) are few quality national registries currently available for acute coronary syndrome. Using data from the MINAP and RIKS-HIA, we propose to investigate (1)the survival trajectories for a reference patient with myocardial infarction and (2) hospital variability in myocardial infarction mortality rate in the UK and Sweden, adjusted for important patient-level and hospital-level covariates.
Trial information was received from ClinicalTrials.gov and was last updated in February 2014.
Information provided to ClinicalTrials.gov by University College, London.