Genomic Analysis of Patients With Chronic Lymphocytic Leukemia
This trial is active, not recruiting.
|Condition||chronic lymphocytic leukemia|
|Sponsor||Universitaire Ziekenhuizen Leuven|
|Start date||April 2010|
|Trial size||53 participants|
|Trial identifier||NCT01346020, S53270|
This study aims to characterize clonal evolution in chronic lymphocytic leukemia (CLL) using different approaches and to identify a possible association with disease progression, i.e. therapy initiation.
1. Samples This monocentric study is carried out using representative bioarchived leukemic samples with a diagnosis of CLL, either at diagnosis or at evolution. These bioarchived samples were collected locally at our center during years of diagnostic activity, and were accurately pathologically, cytogenetically and molecularly characterized.
2. Clinical data The clinical data were retrospectively collected through collaboration with the referring physicians.
3. Methods Samples will be investigated by means of (1) conventional cytogenetics, (2) fluorescence in situ hybridization (FISH) and (3) SNP-arrays. After analysis of the array data sets, significant results will be validated and in addition, results will be correlated with clinical data.
Time to therapy
time frame: baseline to day 1 of therapy
Genetic abnormalities detected by karyotyping, FISH or array-analysis
time frame: 13-102 months
Male or female participants of any age.
Inclusion Criteria: - diagnosis of CLL, - at least two available stored samples Exclusion Criteria: - at least one inclusion criterium not fulfilled
|Official title||Genomic Analysis of Patients With Chronic Lymphocytic Leukemia|
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