Spine Quantitative Computed Tomography (QCT) for the Assessment of Osteoporosis on Children
This trial is active, not recruiting.
|Condition||systemic lupus erythematosus|
|Sponsor||Children's Hospital of Philadelphia|
|Start date||October 2010|
|End date||July 2013|
|Trial size||32 participants|
|Trial identifier||NCT01330368, 10-007747|
The purpose of this study is to compare healthy children to children who have systemic lupus erythematosus (SLE). SLE is a childhood disease that has high risk for low bone mass and vertebral compression fractures.
|Observational model||case control|
Age and sex specific z-scores for lumbar spine (L2) volumetric bone mineral density (BMD) (trabecular and total) and vertebral volume.
time frame: 2 years
Mean lumbar spine stiffness and strength in children with SLE and healthy controls correlation between standard and low dose lumbar spine.
time frame: 2 years
Male or female participants from 5 years up to 21 years old.
Inclusion Criteria: - For SLE subjects: Subjects age 5-21 drawn from rheumatology clinic at Children's Hospital of Philadelphia diagnosed with SLE for at least 1 month. Also subjects with no known vertebral compression fracture of L2. - For Control subjects: Subjects age 5-21. Controls will be a 50% male/female. Exclusion Criteria: - For SLE subjects: Subjects with SLE will be excluded if they have conditions or drug exposure unrelated to SLE and known to impact growth or bone health. - For Control subjects: Chronic disease or syndrome known to affect growth or bone health, prematurity (<37 weeks gestation), or use of any medication known to affect growth.
|Official title||Spine Quantitative Computed Tomography (QCT) for the Assessment of Osteoporosis on Children|
|Principal investigator||Jon Burnham, MD, MSCE|
|Description||The purpose of this research study is to measure bone mass in children with SLE using different measurement techniques. Children with chronic illnesses are at risk of bone fragility. This is important because bone fragility can result in childhood fractures especially children with SLE. Therefore better diagnosis technique can lead to better management of bone health.|
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