This trial is active, not recruiting.

Conditions upper respiratory tract infection, asthma
Treatment arm 1 oral cortico steroids
Phase phase 4
Sponsor University of British Columbia
Start date April 2011
End date May 2012
Trial size 92 participants
Trial identifier NCT01326494, H10-00184


The purpose of this study is to investigate the benefits of giving filled prescription of a medication to be used upon early onset of symptoms of URTI induced asthma. The hope is to reduce the need to present to Health Care centres for treatment.

United States No locations recruiting
Other Countries No locations recruiting

Study Design

Allocation non-randomized
Endpoint classification safety/efficacy study
Intervention model parallel assignment
Masking open label
Primary purpose prevention
(Active Comparator)
A filled prescription will be given to be used upon early onset of symptoms.
arm 1 oral cortico steroids Prednisone
Prednisolone: 1 mg / kg per day course of dose for 5 days up to child's weight of 20 kgs. Dexamethasone: 0.3mg/kg per dose for 3 days (minimum weight 20 kgs )
(No Intervention)
monitor the readmission of URTI induced asthma in children over a 12 month period

Primary Outcomes

Reduction of representation to Health Services for Exacerbation of URTI induced asthma
time frame: One year

Eligibility Criteria

Male or female participants from 12 months up to 18 years old.

Inclusion Criteria: - 2 or more presentations to Emergency department in a 12 month period Exclusion Criteria: - less then 2 presentations to Emergency department in a 12 month period

Additional Information

Official title Reducing the Acute Care Burden of Childhood Asthma on Health Services in British Columbia
Principal investigator Bruce Carleton, B.Pharm, Pharm.D.
Description In Canada, asthma affects more the 12% of children. Exacerbation are a common feature of asthma. In children, upper respiratory tract infection (URTI's) are responsible for over 80% of asthma exacerbation. Experts in asthma care acknowledge this critical problem and have developed guidelines to reduce asthma exacerbation. The criteria for participation in this study to have 2 or more presentations to a Health Service centre in the past 12 months for URTI induced asthma. These patients will be followed and interviewed monthly over a 12 month period to investigate whether the use of Oral cortico-steroids upon early onset of URTI induced asthma prevents the need for presentation to hospital
Trial information was received from ClinicalTrials.gov and was last updated in May 2016.
Information provided to ClinicalTrials.gov by University of British Columbia.