Overview

This trial is active, not recruiting.

Conditions htn, diabetes, heart disease, cancer, alzheimer's disease
Sponsor National Institute on Aging (NIA)
Collaborator University of Maryland
Start date June 2009
Trial size 4000 participants
Trial identifier NCT01323322, 09-AG-N248, 999909248

Summary

The Healthy Aging in Neighborhoods of Diversity across the Life Span study (HANDLS) is a multidisciplinary, community-based, prospective longitudinal epidemiologic study examining the influences of race and socioeconomic status (SES) on the development of age-related health disparities among socioeconomically diverse African Americans and whites in Baltimore. This study investigates whether health disparities develop or persist due to differences in SES, differences in race, or their interaction. This study is unique because it will assess over a 20-year period physical parameters as well as evaluate genetic, biologic, demographic, and psychosocial parameters of African American and white participants in higher and lower SES. It also employs novel research tools, mobile medical research vehicles, in hopes of improving participation rates and retention among non-traditional research participants. The domains of the HANDLS study include: nutrition, cognition, biologic biomarkers, body composition and bone quality, physical function and performance, sociodemographics, psychosocial, neighborhood environment and cardiovascular disease. Utilizing data from these study domains will facilitate understand the driving factors behind persistent black-white health disparities in overall longevity, cardiovascular disease, and cognitive decline.

HANDLS Wave 1, the initial recruitment and examination phase that began in August 2004, is complete. The current protocol outlines the revisit waves of this study HANDLS Wave, 2 entitled, The Association of Personality and Socioeconomic status with Health Status An Interim Follow-up Study, which began in June 2006 under a separate protocol is designed as a telephone interview to occur approximately 18 months after the first visit to the mobile Medical Research Vehicles (MRVs). Wave 2 provides interim contact with study participants, and important interim information regarding their health. The next visit HANDLS Wave 3 will consist of the second visit to the mobile Medical Research Vehicles (MRVs) for a health examination to occur at least 3 years after the first, a telephone interview to include the dietary interview and questionnaires, and for a random sample of those who participate in the revisit a direct measurement of renal function and a brain scan study using M RI to examine the structure of the brain.

United States No locations recruiting
Other Countries No locations recruiting

Study Design

Time perspective prospective

Eligibility Criteria

Male or female participants from 30 years up to 64 years old.

- INCLUSION CRITERIA: Verified HANDLS participants Able to give informed consent Must have valid picture identification EXCLUSION CRITERIA: Pregnancy Current cancer chemotherapy or radiation therapy

Additional Information

Official title Healthy Aging in Neighborhoods of Diversity Across the Life Span (HANDLS)
Principal investigator Michele K Evans, M.D.
Description The Healthy Aging in Neighborhoods of Diversity across the Life Span study (HANDLS) is a multidisciplinary, community-based, prospective longitudinal epidemiologic study examining the influences of race and socioeconomic status (SES) on the development of age-related health disparities among socioeconomically diverse African Americans and whites in Baltimore. This study investigates whether health disparities develop or persist due to differences in SES, differences in race, or their interaction. This study is unique because it will assess over a 20-year period physical parameters as well as evaluate genetic, biologic, demographic, and psychosocial parameters of African American and white participants in higher and lower SES. It also employs novel research tools, mobile medical research vehicles, in hopes of improving participation rates and retention among non-traditional research participants. The domains of the HANDLS study include: nutrition, cognition, biologic biomarkers, body composition and bone quality, physical function and performance, sociodemographics, psychosocial, neighborhood environment and cardiovascular disease. Utilizing data from these study domains will facilitate understand the driving factors behind persistent black-white health disparities in overall longevity, cardiovascular disease, and cognitive decline. HANDLS recruited a fixed cohort as an area probability sample of Baltimore City from August 2004 through November 2009 as Wave 1 (Figure 1). HANDLS Wave 2 entitled The Association of Personality and Socioeconomic status with Health Status An Interim Follow-up Study began in June 2006 under a separate protocol. It was designed as a follow-up telephone interview approximately 18 months after the initial examination (Wave 1) was complete. Wave 2 provided interim contact with study participants, and important interim information regarding their health. Now completed, wave 3 was the first follow-up examination and participants second visit to our mobile Medical Research Vehicles (MRVs). The current protocol outlines Wave 4, the second follow-up examination and participants third visit to our mobile Medical Research Vehicles (MRVs). Planned as a follow-up after 3-4 years, Wave 4 consists of health examinations, a telephone dietary-recall interview, renal function assessments, and optional studies of circadian rhythm, structural MRIs, and an evaluation of the subjective experience of diabetes mellitus.
Trial information was received from ClinicalTrials.gov and was last updated in March 2016.
Information provided to ClinicalTrials.gov by National Institutes of Health Clinical Center (CC).