Overview

This trial is active, not recruiting.

Conditions diabetes, obesity
Sponsor University of South Alabama
Start date December 2009
End date December 2013
Trial size 32 participants
Trial identifier NCT01322035, 09.0027

Summary

This study compares the improvement of weight, fasting lipid profile (triglycerides, cholesterol, HDL, and LDL) and diabetes after gastric bypass surgery with an improvement in levels of an enzyme called glucose-6-phosphate dehydrogenase (G6PD).

United States No locations recruiting
Other Countries No locations recruiting

Study Design

Observational model cohort
Time perspective prospective

Primary Outcomes

Measure
Measure erythrocyte G6PD levels in diabetic vs. non-diabetic morbidly obese patients undergoing laparoscopic Gastric Bypass.
time frame: time of surgery up to 24 months post gastric bypass

Secondary Outcomes

Measure
Measure adipocyte G6PD levels in diabetic vs. non-diabetic morbidly obese patients undergoing laparoscopic gastric bypass.
time frame: time of surgery up to 12 weeks post gastric bypass
Measure omentum G6PD levels in diabetic vs. non-diabetic morbidly obese patients undergoing laparoscopic gastric bypass.
time frame: time of surgery up to 12 weeks post gastric bypass
Measure hepatocyte G6PD levels in diabetic vs. non-diabetic morbidly obese patients undergoing laparoscopic gastric bypass.
time frame: time of surgery up to 12 weeks post gastric bypass

Eligibility Criteria

Male or female participants from 19 years up to 70 years old.

Inclusion Criteria: - Age > 19 years of age and <70 years of age - HGA1c<6.0% - fasting blood sugar less than 100mg/dL Exclusion Criteria: - Taking antidiabetic medications for other indications

Additional Information

Official title Erythrocyte and Adipocyte G6PD Activity Levels Correlate With Differing Degrees of Dyslipidemia, Insulin Resistance and Obesity
Principal investigator William O Richards, MD
Description Same as brief summary
Trial information was received from ClinicalTrials.gov and was last updated in January 2013.
Information provided to ClinicalTrials.gov by University of South Alabama.