This trial is active, not recruiting.

Conditions angina pectoris, microvascular angina, angina pectoris, variant
Sponsor Luzerner Kantonsspital
Start date July 1996
End date July 2018
Trial size 718 participants
Trial identifier NCT01318629, Heart Quest


Many patients undergoing coronary angiography are found to have no significant coronary artery disease (CAD) despite angina equivalent symptoms and/or electrocardiographic abnormalities suggestive of myocardial ischemia. The aim of this study is to systematically assess patients with angina equivalent symptoms despite normal coronary angiograms and to evaluate their symptoms according to a defined algorithm.

United States No locations recruiting
Other Countries No locations recruiting

Study Design

Observational model cohort
Time perspective prospective

Primary Outcomes

Cause of angina equivalent symptoms in patients with no coronary artery disease
time frame: One day
Prognosis of patients with angina equivalent symptoms and normal coronary arteries
time frame: 10 years after baseline assessment

Eligibility Criteria

Male or female participants of any age.

Inclusion Criteria: - Coronary angiography at the Luzerner Kantonsspital between July 1st 1996 and July 31st 2008 - No significant coronary stenoses (no coronary stenoses ≥ 50%) Exclusion Criteria: - Severe valvular heart disease - Severe congestive heart failure

Additional Information

Official title Invasive Findings in Patients With Angina Equivalent Symptoms But No Coronary Artery Disease; Results From the Heart Quest Cohort Study
Principal investigator Paul Erne, MD
Description All consecutive patients who had coronary angiography at the Luzerner Kantonsspital between July 1st 1996 and July 31st 2008 and who had no significant coronary stenoses (no coronary stenoses ≥ 50%) were recruited for this study. Patients are extensively examined during angiography using acetylcholine infusion and fast atrial pacing. According to the result of the additional invasive examination (vasospasm, vasoconstriction, vasodilation; symptoms during examination) a distinct diagnosis is attributed to the patients (small vessel disease, vasospastic disease, hypertensive heart disease, rhythm disorder, or extracardiac thoracic pain including pulmonary hypertension). Patients are followed-up after 10 years and prognosis of these patients is assessed (including mortality, cardiovascular events, re-angiography, functional status after 10 years).
Trial information was received from ClinicalTrials.gov and was last updated in April 2013.
Information provided to ClinicalTrials.gov by Luzerner Kantonsspital.