Overview

This trial is active, not recruiting.

Condition healthy volunteers
Treatment aspirin and clopidogrel
Sponsor University of Rostock
Start date July 2010
End date February 2011
Trial size 25 participants
Trial identifier NCT01264640, LO-0005

Summary

The impact of anti-platelet drugs on the concentrations of Brain-derived neurotrophic factor (BDNF) in human plasma and serum is unknown. It is the aim of this study to investigate the impact of a single dose of Aspirin (500 mg) or Clopdigrel (600 mg) on the concentrations of Brain-derived neurotrophic factor (BDNF) in plasma and serum of healthy volunteers.

United States No locations recruiting
Other Countries No locations recruiting

Study Design

Intervention model single group assignment
Masking open label
Primary purpose basic science
Arm
(Experimental)
Intake of 500 mg Aspirin on day 1. Intake of 600 mg Clopidogrel on day 28. Measurement of platelet inhibition, platelet counts and BDNF, TGF-beta, 5-HT concentrations in peripheral blood on day 1 (before intake of 500 mg Aspirin), day 2 (24 hours after intake of 500 mg Aspirin), day 28 (before intake of 600 mg Clopidogrel), day 29 (24 hours after intake of 600 mg Clopidogrel).
aspirin and clopidogrel
Intake of 500 mg Aspirin on day 1. Intake of 600 mg Clopidogrel on day 28. Blood collection for the measurement of platelet inhibition, platelet counts and BDNF, TGF-beta, 5-HT concentrations in peripheral blood on day 1 (before intake of 500 mg Aspirin), day 2 (24 hours after intake of 500 mg Aspirin), day 28 (before intake of 600 mg Clopidogrel), day 29 (24 hours after intake of 600 mg Clopidogrel).

Primary Outcomes

Measure
BDNF plasma and serum concentration 24 hours after Aspirin or Clopidgrel intake
time frame: 24 hours

Secondary Outcomes

Measure
5-HT and TGF-beta concentrations 24 hours after Aspirin or Clopidgrel intake
time frame: 24 hours

Eligibility Criteria

Male participants from 18 years up to 50 years old.

Inclusion Criteria: - Age 18-50 years - Gender: Male Exclusion Criteria: - Any acute disease - Any chronic disease - Any medication - Allergies / Intolerance in association with Aspirin or Clopidogrel

Additional Information

Official title The Impact of Aspirin and Clopidogrel on Brain-derived Neurotrophic Factor (BDNF) Concentrations in Human Serum and Plasma
Principal investigator Marek Lommatzsch, PD Dr.
Trial information was received from ClinicalTrials.gov and was last updated in December 2010.
Information provided to ClinicalTrials.gov by University of Rostock.