Microvesicle Production After Acute Trauma and Its Clinical Impact on Venothromboembolism
This trial is active, not recruiting.
|Start date||January 2011|
|End date||January 2017|
|Trial size||2720 participants|
|Trial identifier||NCT01264458, 10-001889|
The purpose of this research study is to look at how trauma affects the ability of blood to clot. The blood of people who suffer a traumatic injury can under-clot or over-clot, and this research study will look at blood drawn from people after they suffer a traumatic injury to see how well their blood clots.
|Observational model||case control|
Trauma patients arriving at Saint Mary's Emergency Department
Estimate the distribution over time of procoagulant Microvesicles (MVs) concentration by cell of origin and endogenous thrombin potential (ETP).
time frame: 6 months
Determine the cumulative incidence of Venothromboembolism (VTE) within three months after major trauma and test the distribution of procoagulant MV concentration and endogenous thrombin generation potential over time as potential predictors of VTE.
time frame: 4 years
Male or female participants at least 18 years old.
Inclusion Criteria: - Male and female patients 18 years of age or older - Blunt trauma patients including those with closed head injury - Penetrating trauma patients Exclusion Criteria: - Are on therapeutic anticoagulation - Have preexisting coagulopathy - Patients greater than 12 hours from time of injury - Have history of malignancy or preexisting diagnosis of sepsis or renal failure - Patients with burn injuries - Male and female patients younger than 18 years of age - Pregnant patients
|Official title||Microvesicle Production After Acute Trauma and Its Clinical Impact on Venothromboembolism|
|Principal investigator||Myung Park, M.D.|
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