This trial is active, not recruiting.

Condition differentiated thyroid cancer
Treatments everolimus, sorafenib
Phase phase 2
Targets VEGF, RAF, PDGF, mTOR, FKBP-12, FLT-3, KIT
Sponsor Abramson Cancer Center of the University of Pennsylvania
Collaborator Bayer
Start date November 2010
End date November 2014
Trial size 40 participants
Trial identifier NCT01263951, 812004, UPCC 19309


The goal of this study is to determine the effect of combining everolimus and sorafenib in patients with metastatic differentiated thyroid cancer who progressed on sorafenib alone.

United States No locations recruiting
Other Countries No locations recruiting

Study Design

Intervention model single group assignment
Masking open label
Primary purpose treatment
All patients will receive everolimus and sorafenib daily.
everolimus Afinitor
One 5 mg. tablet daily.
sorafenib Nexavar
200 mg. twice daily.

Primary Outcomes

To determine the efficacy of everolimus and sorafenib (progression free survival, objective response rate and stable disease) in patients with advanced differentiated thyroid cancer who have progressed on sorafenib alone.
time frame: Every 4 weeks

Secondary Outcomes

To evaluate the secondary endpoints of best response in patients receiving everolimus and sorafenib.
time frame: Every 4 weeks
To perform correlative scientific studies to determine the relationship between clinical response to everolimus and sorafenib and multiple parameters including the mutational status of BRAF, N-RAS and other relevant cancer genes in the tumor.
time frame: Every 4 weeks
To investigate the effectiveness of mTOR and Raf kinase inhibition in surrogate tissue and tumor samples.
time frame: Every 4 weeks
To evaluate the activity of additional signaling pathways in surrogate tissue and tumor samples and explore their relevance to outcome measures.
time frame: Every 4 weeks
To evaluate the secondary endpoints of time to disease progression in patients receiving everolimus and sorafenib.
time frame: Every 4 weeks
To evaluate the secondary endpoints of duration of response in patients receiving everolimus and sorafenib.
time frame: Every 4 weeks

Eligibility Criteria

Male or female participants from 18 years up to 89 years old.

Inclusion Criteria: - Diagnosis of thyroid cancer, that is metastatic or unresectable and for which standard curative or palliative measures do not exist or are no longer effective. - All patients will have been required to have had sorafenib for entry and have had documented progression while on previous treatment with sorafenib. - Measurable disease defined as at least one malignant lesion that can be accurately measured on computerized tomography (CT) and/or magnetic resonance imaging (MRI) scan. - ECOG performance status < 2. - Life expectancy greater than 3 months. - Intellectual, emotional, and physical ability to comply with oral medication. Exclusion Criteria: - Restrictions regarding certain prior treatments will apply. - Significant medical disease including: uncontrolled congestive heart failure; active symptoms of coronary artery disease, uncontrolled seizure disorder; active infection; uncontrolled diabetes mellitus; requirement for chronic high dose corticosteroid treatment (Topical or inhaled corticosteroids are allowed); requirement for concurrent immunosuppressive drug(s); active autoimmune disease. - Organ allografts. - Known HIV-infection (HIV testing is not required for participation). - Pregnant or breast feeding. Women of childbearing potential and sexually active males must be advised to take precautions to prevent pregnancy during treatment - History of second cancer (except adequately treated basal cell or squamous cell skin cancer, in situ treated cervical cancer, colon cancer or melanoma, or any other cancer for which the patient has been disease-free for three or more years). - Known hypersensitivity to everolimus or other rapamycins (e.g., sirolimus, temsirolimus) or to its excipients - Use of any experimental therapy within 4 weeks prior to baseline evaluations done prior to enrollment (with the exception of sorafenib which may be continued until treatment start). Therefore, all experimental treatments other than sorafenib must be discontinued 4 weeks prior to baseline studies or enrollment. - Patients who did not previously tolerate sorafenib at 200 mg once daily are excluded from the study.

Additional Information

Official title A Phase II Study of Everolimus and Sorafenib in Patients With Metastatic Differentiated Thyroid Cancer Who Have Progressed on Sorafenib Alone
Principal investigator Marcia Brose, MD, PhD
Description The purpose of this research study is to: 1. Find out if sorafenib and everolimus prevent the growth of tumors that have grown when treated with sorafenib alone 2. Find out how long one might benefit from treatment with sorafenib and everolimus 3. Find out what side effects this drug may cause 4. Measure the amount of sorafenib and everolimus in the blood and see if "markers" can be found to help understand who might benefit from sorafenib and everolimus.
Trial information was received from ClinicalTrials.gov and was last updated in December 2015.
Information provided to ClinicalTrials.gov by Abramson Cancer Center of the University of Pennsylvania.