This trial is active, not recruiting.

Condition body burden of potentially toxic lipophilic compounds
Treatment olestra
Sponsor Ronald Jandacek
Collaborator National Institute of Environmental Health Sciences (NIEHS)
Start date December 2010
End date April 2012
Trial size 28 participants
Trial identifier NCT01261338, 10100801 1R21ES019206-01, 1R21ES019206-01


Because of industrial pollution, a large number of people in Annison, Alabama, have elevated body burdens of the class of compounds known as polychlorinated biphenyls (PCBs). There is evidence that these compounds are associated with risks to health including diabetes. There is also evidence that the consumption of a non-absorbable dietary fat can reduce the level of compounds like PCBs. This clinical trial will test the hypothesis that a non-absorbable dietary fat can reduce the levels of PCBs in subjects in Anniston.

United States No locations recruiting
Other countries No locations recruiting

Study Design

Allocation randomized
Endpoint classification pharmacokinetics study
Intervention model parallel assignment
Masking double blind (subject, investigator)
Primary purpose basic science
Non-absorbable fat
non-absorbable dietary fat

Primary Outcomes

Rate of change of blood levels of PCBs.
time frame: one year

Eligibility Criteria

Male or female participants from 21 years up to 75 years old.

Inclusion Criteria: - Elevated blood level of PCBs Exclusion Criteria: - Pregnancy - Breast-feeding - Weight-loss medication - Gastrointestinal disease

Additional Information

Official title Intervention to Reduce Body Burdens of PCBs in Residents of Anniston, Alabama
Principal investigator Ronald J Jandacek, Ph.D.
Trial information was received from ClinicalTrials.gov and was last updated in October 2012.
Information provided to ClinicalTrials.gov by University of Cincinnati.