This trial is active, not recruiting.

Condition healthy
Treatment 15n-thymidine, 2h-water
Sponsor Brigham and Women's Hospital
Start date December 2010
End date December 2016
Trial size 20 participants
Trial identifier NCT01257997, BWH-2010p001900


This pilot study is using a novel technology to measure the rate of turnover of new fat cells. Analysis of volunteer samples is ongoing, however the study is currently not enrolling new volunteers.

United States No locations recruiting
Other countries No locations recruiting

Study Design

Time perspective prospective
18-49 year old healthy men and women. Free of significant chronic medical illness and illicit substance abuse. Body mass index from 20 to 27.
15n-thymidine, 2h-water
Stable isotope 15N-thymidine, infused IV (15mg/hour) for 72 hours (phase 1 pilot). Stable isotope 2H-water, ingested by mouth once per day for 3 days (phase 1 pilot) or 28 days (phase 2 pilot).

Primary Outcomes

Quantifying human adipogenesis-counting the number of new fat cells.
time frame: 4 weeks-7 months

Eligibility Criteria

Male or female participants from 18 years up to 49 years old.

Inclusion Criteria: - Aged 18-49 years. - Healthy. Exclusion Criteria: - Significant chronic medical illness. - Illicit substance or alcohol abuse. - Body mass index > 27 kg/meters squared. - Underweight (BMI < 20 kg/m2). - History of keloid formation (excessive scarring). - Pregnant.

Additional Information

Official title Quantification of Human Adipogenesis
Principal investigator Matthew L Steinhauser, MD
Trial information was received from ClinicalTrials.gov and was last updated in August 2016.
Information provided to ClinicalTrials.gov by Brigham and Women's Hospital.