This trial is active, not recruiting.

Conditions sister-chromatic-exchange(sce), micronuclei(mn)
Sponsor Taipei Medical University WanFang Hospital
Start date October 2010
End date December 2011
Trial size 200 participants
Trial identifier NCT01253057, 99061


Several epidemiological studies found that exposure to antineoplastic agents were associated with some reproductive, carcinogenic effects, higher rates of advance micronuclei (MN), sister-chromatic-exchange (SCE) and spontaneous abortion. Cleaning staff were potentially exposed to these agents while cleaning ward, ward toilet or other area.

One medical center and one area hospitals in Taipei.Surface wipe samples were collected in the cleaning staff work area, such as ward environment and ward toilet. Urine and blood samples of subjects were collected for exposure examinations. Platinum-containing drugs (Cisplatin, Carboplatin, Oxaliplatin) were used as indicator drugs in environmental (surface wipe samples) and biological (urine and blood samples) samples.

A self-administered questionnaire was used to collect demographic data, working practices, medical and contact history, and perceived work-related symptoms of cleaning staff.

The results of this study will be to reduce exposure to cleaning staff.

United States No locations recruiting
Other Countries No locations recruiting

Study Design

Observational model case control

Eligibility Criteria

Male or female participants of any age.

Inclusion Criteria: - Only included those who signed the consent study Exclusion Criteria: - none

Additional Information

Official title A Research on the Hospital Pollution Control and Hygine Intervention of Chemotherapy Drugs Exposure
Principal investigator Ruey-Yu Chen
Trial information was received from ClinicalTrials.gov and was last updated in December 2010.
Information provided to ClinicalTrials.gov by Taipei Medical University WanFang Hospital.