Acute Effect of Transcutaneous Electrical Nerve Stimulation in Heart Failure
This trial is active, not recruiting.
|Conditions||improvement of cardiovascular autonomic control, reduction of levels of catecholamines|
|Treatment||transcutaneous electrical nerve stimulation|
|Sponsor||Federal University of Health Science of Porto Alegre|
|Collaborator||Coordenação de Aperfeiçoamento de Pessoal de Nível Superior.|
|Start date||November 2010|
|End date||March 2013|
|Trial size||30 participants|
|Trial identifier||NCT01252407, TensIC|
The purpose of this study is to determine acute effect the transctutaneous electrical nerve stimulation in sympathetic and parassympathetic system in individuals with heart failure.
|Endpoint classification||efficacy study|
|Intervention model||parallel assignment|
|Masking||double blind (subject, outcomes assessor)|
differences in blood levels of catecholamines differences in blood levels of catecholamines differences in blood levels of catecholamines Differences in blood levels of catecholamines
time frame: one minute before and after transutaneous electrical nerve stimulation intervention (acute effect)
improvement of heart rate variability
time frame: one minute before and after transcutaneous electrical nerve stimulation intervention (acute effect)
Male or female participants from 18 years up to 70 years old.
- Possess stable heart failure grade II or III according to NYHA;
- Ejection fraction <40% determined by echocardiography;
- Having no change in drug therapy one month before being included in the study;
- There have been Myocardial Infarction (AMI) three months before study entry;
- Patients with grade IV heart failure according to NYHA;
- Acute respiratory;
- Unstable angina;
- Ventricular arrhythmia, unstable until three months before the start of the study;
- Active smoking;
- Diabetes mellitus;
- And fever or infectious disease.
|Official title||Acute Effect of Transcutaneous Electrical Nerve Stimulation on the Sympathetic and Parasympathetic Systems in Individuals With Heart Failure|
|Description||Heart failure (HF) is the inability of the heart to maintain adequate levels of blood supply to tissues. In recent years there has been an increased prevalence of heart failure (HF), in Brazil there are about two million people diagnosed with HF and 240,000 new cases per year. Thus, the IC constitutes the most serious problem now and in the fields of cardiology and public health. Sympathetic activity is increased and correlates with a worse prognosis and survival in these patients. Currently, the pharmacological blockade of the sympathetic system by chronic use of beta-blockers are commonly used to treat hyperactivity, but these interventions have side effects. The transcutaneous electrical nerve stimulation (TENS) has been used successfully to control pain in different clinical conditions and may be a noninvasive strategy to reduce drug and not the severity of increased sympathetic.|
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