This trial is active, not recruiting.

Conditions bronchitis, cough
Treatment demonstration of near zero antibiotic prescribing for patients with acute bronchitis
Sponsor Brigham and Women's Hospital
Collaborator Agency for Healthcare Research and Quality (AHRQ)
Start date March 2011
End date June 2014
Trial size 400 participants
Trial identifier NCT01240174, 2010P001247


Studies show, guidelines state, and performance measures assert that antibiotic prescribing for uncomplicated acute bronchitis is inappropriate. However, clinicians prescribe antimicrobials in over 60% of the 22.5 million acute bronchitis visits in the United States each year. Previous successful interventions have only reduced the antimicrobial prescribing rate to 40% or 50%. It is unknown if the antimicrobial prescribing rate for acute bronchitis can be brought to near zero percent in actual practice while maintaining patient safety and satisfaction. The goal of this study is to develop an Electronic Health Record (EHR)-integrated algorithm for the diagnosis and treatment of adults with acute bronchitis with a goal of reducing the antibiotic prescribing rate to near zero percent.

United States No locations recruiting
Other Countries No locations recruiting

Study Design

Endpoint classification efficacy study
Intervention model single group assignment
Masking open label
Primary purpose health services research

Primary Outcomes

Antibiotic prescribing rate
time frame: 30 days

Secondary Outcomes

Patient symptoms
time frame: 21 days
Patient satisfaction
time frame: 21 days
Patient safety
time frame: 30 days
Healthcare costs
time frame: 30 days
The capture and description of the components that had the greatest effect on the antimicrobial prescribing rate
time frame: 3 years

Eligibility Criteria

Male or female participants from 18 years up to 64 years old.

Inclusion Criteria: - first visit in 30 days, age 18-64, has a cough of less than 3 weeks duration Exclusion Criteria: - infiltrate on chest x-ray, has chronic lung disease

Additional Information

Official title Demonstration of Near Zero Antibiotic Prescribing for Acute Bronchitis
Principal investigator Jeffrey A Linder, MD, MPH
Description We will use a multi-modal implementation - including computerized decision support, reporting tools, and clinician feedback - and quality improvement techniques to ensure adherence to the algorithm and reduce the antimicrobial prescribing rate to near zero percent. The duration of the intervention will be 4 years.
Trial information was received from ClinicalTrials.gov and was last updated in June 2014.
Information provided to ClinicalTrials.gov by Brigham and Women's Hospital.