This trial is active, not recruiting.

Conditions osteoarthritis, knee replacement
Sponsor Coxa, Hospital for Joint Replacement
Collaborator University of Tampere
Start date December 2009
End date June 2013
Trial size 460 participants
Trial identifier NCT01236729, KL122009


Knee replacement is an effective treatment in late-stage osteoarthritis. It reduces pain and improves quality of life. There is, however, limited data concerning its results in older people and on its effect on how patients survive in regular activities of daily living (ADL), such as bathing and shopping. In this study, the results of knee replacement are evaluated from the point of view of disability in everyday activities and self-rated health. Moreover, association with ADL performance and clinical knee scores and severity of osteoarthritis are assessed.

United States No locations recruiting
Other Countries No locations recruiting

Study Design

Observational model cohort
Time perspective cross-sectional
Patients (aged 75 years or over) with late-stage arthritis who have undergone or are undergoing primary knee replacement

Primary Outcomes

Disability in activities of daily living
time frame: Baseline (recruitment) and at 12 months

Secondary Outcomes

Overall self-rated health
time frame: Baseline (recruitment) and at 12 months
Health-related quality of life (WOMAC)
time frame: Baseline and 12 months postoperatively

Eligibility Criteria

Male or female participants at least 75 years old.

Inclusion Criteria: - age 75 years or more at the time of operation - diagnosis of knee osteoarthritis - scheduled for or operated on with primary knee replacement Exclusion Criteria: - died during the follow-up - inflammatory arthritides

Additional Information

Official title The Effects of Primary Knee Replacement for Osteoarthritis on Disability in Activities of Daily Living and Self-rated Health in Older People
Description This is a cross-sectional study with a 12 month follow-up for recruited patients. Most data are gathered by a postal questionnaire.
Trial information was received from ClinicalTrials.gov and was last updated in August 2015.
Information provided to ClinicalTrials.gov by Coxa, Hospital for Joint Replacement.