Progressive Strength Training in Spinal Muscular Atrophy
This trial is active, not recruiting.
|Condition||muscular atrophy, spinal|
|Treatment||progressive strength training|
|Sponsor||University of Utah|
|Start date||June 2010|
|End date||June 2013|
|Trial size||12 participants|
|Trial identifier||NCT01233817, 39995|
The proposed feasibility study is necessary to test if children and young adults will participate in and adhere to a 12-week, home-based, supervised progressive strength training exercise program and to obtain preliminary data that will subsequently allow us to determine the safety and impact of strength training in spinal muscular atrophy. Our pilot study will address 3 aims: (1) Ascertain the feasibility of, and potential barriers to, participation in and adherence to a 12-week home-based, supervised, progressive strength training exercise program in children and young adults aged 5-21 years with SMA types II and III; (2) Determine the safety and tolerability of progressive strength training in a pilot study sample of children and young adults with SMA types II and III; and (3) Determine candidate outcome measures.
|Endpoint classification||safety/efficacy study|
|Intervention model||single group assignment|
time frame: 12 weeks
Male or female participants from 5 years up to 21 years old.
Inclusion Criteria: - age 5-21 years - diagnosis of SMA type II or III - at least antigravity strength in elbow flexors - ability to follow commands and stay on task - place of residence within a 60-minute or 60-mile drive of the University of Utah Exclusion Criteria: - planned surgery or out-of-town trips during the proposed intervention period - inability to travel to study center for testing - neurological diagnosis other than SMA
|Official title||Pilot Study of Progressive Strength Training in Spinal Muscular Atrophy|
|Principal investigator||Aga Lewelt, MD|
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