This trial is active, not recruiting.

Condition multiple sclerosis
Treatments exercise, stretching
Phase phase 1/phase 2
Sponsor University of California, Los Angeles
Collaborator California State University, Northridge
Start date July 2010
End date July 2014
Trial size 50 participants
Trial identifier NCT01219647, RG 4174A5/2


Many persons with Multiple Sclerosis ( MS) have problems with memory and thinking.Exercise has been shown to improve memory and thinking in persons with diseases such as Alzheimer's. This study will investigate whether a program of aerobic exercise can improve memory and thinking in persons with MS

United States No locations recruiting
Other countries No locations recruiting

Study Design

Allocation randomized
Endpoint classification safety/efficacy study
Intervention model parallel assignment
Masking single blind (outcomes assessor)
Primary purpose treatment
Subjects will train on a recumbent cross trainer 20-30 minutes/session for three times/week for six months under supervision of a fitness specialist
subjects will participate in one of two forms of exercise
(Active Comparator)
Subjects will particiate in supervised stretching at same frauency, duration and intensity of aerobic exericse arm
subjects will particiopate in supervised stretching as described in arm description.

Primary Outcomes

Paced Auditory Serial Addition Test (PASAT)
time frame: 36 weeks

Secondary Outcomes

Symbol Digit Modalities Test (SDMT)
time frame: 36 weeks
VO2 max
time frame: 36 weeks
Long latency cognitive event related potentials ( LLCERP)
time frame: 36 weeks

Eligibility Criteria

Male or female participants from 18 years up to 60 years old.

Inclusion Criteria: - Clinical Diagnosis of MS Complaints of cognitive problems Able to ride a recumbent cross trainer Exclusion Criteria: - Cardiopulmonary or structural disease that would limit ability to participate in exercise training On treatment with chemotherapy or natalizumab Screening score of >50 on PASAT

Additional Information

Official title Exercise as a Strategy to Treat Cognitive Dysfunction in Persons With Multiple Sclerosis
Principal investigator Barbara Giesser, MD
Description Persons with Multiple Sclerosis(MS)will be screened for eligibility and randomized to a protocol with two intervention arms. One group will have aerobic training on a recumbent cross trainer three times a week for 20-30 minutes/session. The other group will participate in stretching exercises at the same frequency and intensity.Total training time will be six months.Outcome measures will include tests of memory and thinking, and fitness measures.
Trial information was received from ClinicalTrials.gov and was last updated in November 2013.
Information provided to ClinicalTrials.gov by University of California, Los Angeles.