This trial is active, not recruiting.

Condition alzheimer's disease
Treatment 18f-flutemetamol
Phase phase 2
Sponsor University of Utah
Start date May 2011
End date May 2016
Trial size 27 participants
Trial identifier NCT01202994, 43306


Alzheimer's disease (AD) is the most common cause of progressive cognitive decline in the United States. AD is characterized by severe impairments in learning, memory and other cognitive abilities that significantly interfere with daily functioning. The neuropathologic hallmarks of AD consist of neuritic plaques, neurofibrillary tangles, and selective neuronal cell loss. Amyloid plaques, which contain Abeta protein, are believed to play an integral role in the development of AD. Elevated levels of Abeta in the brain are also correlated with cognitive decline.

Alzheimer's (AD) develops insidiously, making it difficult to identify early, yet treatment is most effective when begun during the early stages of the disease. Thus, it has become important for researchers to identify markers of early AD. This project will examine the relationship between four potential markers that may indicate the early development of AD:

1. Mild cognitive impairment (MCI)or normal cognition

2. Practice effects

3. Amyloid plaque binding on 18F-PIB PET

4. Glucose hypometabolism on FDG PET

This project will recruit 25 subjects from an ongoing community-based study of memory and practice effects in cognitively normal, community-dwelling individuals who are age 65 and over (NIA #5K23AG028417-05). Each subject will undergo positron emission tomography (PET) with both 18F-Flutemetamol and FDG.

The overall objective of this companion project is to study the biodistribution and binding of 18F-Flutemetamol in these subjects using PET imaging, which will provide biological evidence to support the overall hypothesis that failure to benefit from practice on a learning paradigm is an early marker of AD.

United States No locations recruiting
Other Countries No locations recruiting

Study Design

Endpoint classification bio-availability study
Intervention model single group assignment
Masking open label
Primary purpose screening

Primary Outcomes

Practice effects and FDG-PET perfusion will be correlated with amyloid deposition in 18F-PIB.
time frame: All measures will be collected within six month.

Eligibility Criteria

Male or female participants at least 65 years old.

Inclusion Criteria: - Subjects must be currently enrolled in an NIA-sponsored, community-based study of practice effects in non-demented adults age 65 and older living independently (NIA #5K23AG028417-05) Exclusion Criteria: - History of neurological disease known to affect cognition (e.g., stroke, head injury with loss of consciousness of >30 minutes, seizure disorder, demyelinating disorder, mental retardation, etc.) - Dementia based on DSM-IV criteria - Current or past major psychiatric illness (e.g., schizophrenia, bipolar affective disorder) - 30-item Geriatric Depression Score >14 - Evidence of stroke or mass lesion on CT or MRI scan - History of alcoholism or other substance abuse - Current use of cholinesterase inhibitors, other cognitive enhancers, antipsychotics, or anticonvulsant medications - History of radiation therapy to the brain - History of significant major medical illnesses, such as cancer or AIDS - Uncontrolled diabetes or blood glucose >180 mg/dl on the day of the FDG-PET scan - Currently pregnant

Additional Information

Official title Practice Effects and Amyloid Imaging Using 18F-PIB (18F-39-F-6-OH-BTA1) Known as [18FGE067]) or Flutemetamol PET and FDG-PET
Principal investigator Kevin Duff, Ph.D.
Description The overall objective of this companion study project is to study the biodistribution and binding of 18F-Flutemetamol using PET imaging in community-dwelling functionally intact elderly subjects. Understanding the biodistribution and binding of this radiopharmaceutical in normal patients with various levels of potential for cognitive decline will help determine its appropriate role as a disease biomarker and aid in the interpretation of images produced with this agent. Comparison with FDG-PET is essential to correlate metabolic changes and for anatomic co-registration of 18F-PIB images necessary for group analysis. We will use 18F-Flutemetamol and FDG-PET to compare subjects with low and high practice effects with the following aims and hypotheses: Specific Aim 1: Examine the relationship between practice effects and amyloid burden in a community sample. Specific Aim 2: Determine whether FDG-PET or 18F-Flutemetamol better distinguish individuals with high and low practice effects. Hypothesis 1: Practice effects will be negatively correlated with amyloid deposition, so that higher levels of practice effects (i.e., better repeat testing) will be associated with lower levels of brain amyloid deposition and lower levels of practice effects (i.e., poorer repeat testing) will be associated with greater levels of brain amyloid and these two groups are more clearly distinguishable with 18F-PIB than FDG-PET. Hypothesis 2: Patients with increased amyloid deposition shown with 18F-PIB will have an FDG-PET scan with more pronounced temporal and parietal hypometabolism as noted on visual review of images and on statistical image analysis.
Trial information was received from ClinicalTrials.gov and was last updated in June 2016.
Information provided to ClinicalTrials.gov by University of Utah.