Overview

This trial is active, not recruiting.

Condition pregnancy outcome after in vitro fertilization (ivf)
Treatment in vitro fertilization
Phase phase 4
Sponsor Universitair Ziekenhuis Brussel
Collaborator BioGenesis
Start date January 2007
End date January 2011
Trial size 200 participants
Trial identifier NCT01191710, ProgRise001

Summary

The aim is to explore whether the incidence of progesterone rise in the late follicular phase differs between GnRH-agonist and GnRH-antagonist protocols for IVF and whether this has an impact on the probability of pregnancy achievement.

United States No locations recruiting
Other Countries No locations recruiting

Study Design

Allocation randomized
Endpoint classification efficacy study
Intervention model parallel assignment
Masking open label
Primary purpose treatment
Arm
(Experimental)
Antagonist protocol for IVF
in vitro fertilization IVF
In vitro fertilization procedure with gonadotropin induced follicular ovarian stimulation
(Active Comparator)
Long Agonist protocol for IVF
in vitro fertilization IVF
In vitro fertilization procedure with gonadotropin induced follicular ovarian stimulation

Primary Outcomes

Measure
Incidence of late progesterone rise on the day of HCG triggering
time frame: Up to delivery (2010)

Secondary Outcomes

Measure
Clinical pregnancy rate Delivery rate
time frame: Up to delivery (2010)

Eligibility Criteria

Female participants from 21 years up to 39 years old.

Inclusion Criteria: - age < 39 - follicle-stimulating hormone (FSH) < 12 - gonadotropin dose 100-300IU Exclusion Criteria: - endometriosis - known endocrine disorder - blood analyzed in another laboratory

Additional Information

Official title Is the Clinical Outcome Affected by the Incidence of Progesterone Elevation on the Day of hCG Triggering When Agonist Protocol is Compared to Antagonist Protocol for IVF
Description In view of the current debate concerning possible differences in efficacy between the two GnRH analogues, the current study aimed to explore whether progesterone control in the late follicular phase differs when GnRH-agonist is used as compared to GnRH-antagonist and if so to what extend does the progesterone rise have an impact on the probability of achieving a pregnancy.
Trial information was received from ClinicalTrials.gov and was last updated in September 2010.
Information provided to ClinicalTrials.gov by Universitair Ziekenhuis Brussel.