Corneal Biomechanics With Hydration in Normal and LASIK Eyes
This trial has been completed.
|Condition||laser corneal surgery|
|Treatments||lasik surgery, no intervention|
|Start date||February 2004|
|End date||December 2012|
|Trial size||44 participants|
|Trial identifier||NCT01183702, 2004H002|
The research will utilize LASIK and non-LASIK populations to analyze the biomechanical differences between these corneas.
|Intervention model||parallel assignment|
|Primary purpose||basic science|
Corneal hydration (swelling)
time frame: Two hours
All participants from 18 years up to 60 years old.
Inclusion Criteria: - Healthy cornea without LASIK surgery as determined by a registered ophthalmologist. - Healthy cornea with LASIK surgery as determined by a registered ophthalmologist. Exclusion Criteria: - Children under 18. - Unhealthy cornea as determined by a registered ophthalmologist.
|Official title||Analysis of Corneal Biomechanics Based Upon Central and Peripheral Corneal Thickness in Normal and Post Refractive Surgery Eyes|
|Principal investigator||Deborah M Grzybowski, PhD|
|Description||The research will utilize LASIK and non-LASIK populations to analyze the biomechanical differences between these corneas. Subjects' corneas will be swelled with warmed, humidified nitrogen using modified diving goggles to assess structural changes due to a two hour swelling period. Subjects will be examined prior to swelling by a registered ophthalmologist to ensure that the cornea is healthy enough to undergo the swelling procedure. Pre-swelling and post-swelling data will be compared for parameters such as elasticity, density, thickness, axial and tangential curvature, hydration, and intraocular pressure in the central, paracentral, and peripheral regions. Analysis of pre-swelling and post-swelling data will allow for a better understanding of the structural changes created by LASIK. In addition, this project will allow for a better understanding of how common fluctuations in hydration levels affect normal corneal parameters as given by common devices in both populations to allow for corrections for more accurate measurements.|
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