Change in Ocular Flora Resistance From Repeated Topical Antibiotic Use
This trial is active, not recruiting.
|Conditions||increased drug resistance, infection resistant to quinolones and fluoroquinolones|
|Sponsor||Sunnybrook Health Sciences Centre|
|Start date||June 2010|
|End date||December 2012|
|Trial size||168 participants|
|Trial identifier||NCT01181713, SBK-OcuFResis|
The purpose of this study is to determine if antibiotic resistance of the ocular surface flora to the 4th generation fluoroquinolones will increase after repeated use of topical antibiotics for three days post intravitreal injection.
|Observational model||case control|
No prophylactic antibiotic post intravitreal injection
Group treated with 3 day course of prophylactic topic antibiotic, fourth generation fluoroquinolones, after each intravitreal injection
ocular flora resistance to 4th generation fluoroquinolone
time frame: 1 year
Male or female participants at least 65 years old.
Inclusion Criteria: - patients scheduled for intravitreal injection for neovascular age-related macular degeneration (ARMD) - 65 years or older - able to provide informed consent. Exclusion Criteria: - diagnosed with an active ocular, periocular or systemic infection - previously received treatment with an intravitreal injection - previously treated with antibiotics in the past three months - unable to attend the scheduled follow-up appointments or to complete treatment for any reason
|Official title||Antibiotic Resistance of Ocular Surface Flora After Continued Use of Topical Antibiotics Post Intravitreal Injections|
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